General
Preferred name
GRANISETRON
Synonyms
BRL 43694 ()
BRL 43694A ()
Granisetron HCl ()
GRANISETRON HYDROCHLORIDE ()
[3H]granisetron ()
Granisetron (Hydrochloride) ()
BRL-43694A ()
Bema granisetron ()
Granisteron hydrochloride ()
Granisol ()
Kytril ()
Granisetron hydrochloride preservative free ()
NSC-759839 ()
Granisetron (as hydrochloride) ()
[3H]granisetron ()
APF-530 ()
Sancuso ()
LY-278584 ()
BRL-43694 ()
Sustol ()
APF530 ()
P&D ID
PD009662
CAS
107007-99-8
109889-09-0
Tags
available
drug
Drug indication
Discovery agent
Chemotherapy-induced nausea and vomiting
Drug Status
approved
Max Phase
4.0
First approval
1993
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Granisetron (Hydrochloride) (BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
PRICE 29
DESCRIPTION Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
DESCRIPTION alpha5-selective GABAA inverse agonist (Tocris Bioactive Compound Library)
DESCRIPTION Granisetron hydrochloride (Granisetron HCl) is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
1
Compound Sets
20
AdooQ Bioactive Compound Library
A10437
ChEMBL Approved Drugs
CHEMBL1237080
CHEMBL289469
ChEMBL Drugs
CHEMBL1237080
CHEMBL289469
Concise Guide to Pharmacology 2017/18
2292
Concise Guide to Pharmacology 2019/20
2292
Concise Guide to Pharmacology 2021/22
2292
Concise Guide to Pharmacology 2023/24
2292
CZ-OPENSCREEN Bioactive Library
DrugMAP
DMTM7W0
DMB9VGW
DrugMatrix
Guide to Pharmacology
2292
Ki Database
BRL 43694
GRANISETRON
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL289469
Mcule NIBR MoA Box Subset
MCULE-9596720208
MedChem Express Bioactive Compound Library
HY-B0071A
HY-B0071
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
Granisetron-Hydrochloride
TargetMol Bioactive Compound Library
T1042
The Spectrum Collection
Tocris Bioactive Compound Library
2903
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
312.2
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
2.32
TPSA
50.16
Fraction CSP3
0.56
Chiral centers
2.0
Largest ring
6.0
QED
0.93
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT
5-HT Receptor
Primary Target
5-HT3 Receptors
MOA
Antagonist
5-HT3 receptor antagonist
Member status
member
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data