General
Preferred name
METHDILAZINE
Synonyms
Methdilazine ()
Methdilazine (hydrochloride) ()
METHDILAZINE HYDROCHLORIDE ()
METHDILAZINE HYDROCHLORIDE (200 MG) ()
Tacaryl ()
Methdilazine hcl ()
NSC-169091 ()
P&D ID
PD009655
CAS
1982-37-2
1229-35-2
Tags
available
drug
Approved by
FDA
Drug Status
approved
withdrawn
Drug indication
Antipruritic
Allergic rhinitis
Max Phase
Phase 4
First approval
1982
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Methdilazine is an antihistamine drug, with anticholinergic activity.
(GtoPdb)
DESCRIPTION
This active molecular is a first-generation antihistamine and belongs to phenothiazine class. Methdilazine Hydrochloride is a Histamine H1 receptor antagonist with anticholinergic properties and can be used for the treatment of hypersensitivity reactions and pruritic skin disorders.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
16
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
Ki Database
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
41
Molecular Weight
296.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
4.24
TPSA
6.48
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
ATC
R06AD04
Therapeutic Class
Antihistamines
Pathway
Anti-infection
GPCR/G protein
Immunology/Inflammation
Neuronal Signaling
Target
antibiotic
Bacterial
Histamine Receptor
Solubility
DMSO (Slightly, Methanol (Slightly), Water (Slightly))
Source data
