General
Preferred name
tiagabine
Synonyms
TIAGABINE HYDROCHLORIDE ()
TGB hydrochloride hydrate ()
NO050328 ()
NO328 ()
TGB ()
Tiagabine hydrochloride hydrate ()
NO050328 hydrochloride hydrate ()
NO328 hydrochloride hydrate ()
NO328 hydrochloride ()
TGB hydrochloride ()
NO050328 hydrochloride ()
Gabitril hydrochloride ()
Gabitril ()
Tiagabine HCl ()
Tiagabine (hydrochloride) ()
TIAGABINE HCl ()
Gabitril hydrochloride, NO050328 hydrochloride, NO328 hydrochloride, TGB hydrochloride ()
NO-05-0328 ()
NO-050328 ()
ABBOTT-70569.1 ()
ABBOTT-70569 HYDROCHLORIDE ()
NNC-050328 ()
ABBOTT-70569 ()
NNC-05-0328 ()
ABBOTT-705691 ()
ABBOTT-70569.HCl ()
ABT-569 ()
ABT-569 FREE BASE ()
ABBOTT-70569 FREE BASE ()
A-70569-1 ()
NO-050328 FREE BASE ()
NNC-050328 FREE BASE ()
ABBOTT-705691 FREE BASE ()
ABBOTT-70569-1 ()
Tiagabine-d6 (hydrochloride) ()
P&D ID
PD009653
CAS
145821-59-6
115103-54-3
1006863-69-9
1217808-68-8
Tags
natural product
drug
available
Approved by
FDA
First approval
1997
Drug Status
investigational
approved
Drug indication
Anticonvulsant
Epilepsy
Anxiety disorder
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tiagabine is classified as a GABA reuptake inhibitor (GRI) as it blocks the GABA transporter 1 (GAT-1; gene symbol SLC6A1). (GtoPdb)
DESCRIPTION Phosphate reservoir (Tocris Bioactive Compound Library)
DESCRIPTION Tiagabine is a selective gamma-aminobutyric acid (GABA) reuptake inhibitor. (BOC Sciences Bioactive Compounds)
DESCRIPTION GABA uptake inhibitor; anticonvulsant (Tocriscreen Plus)
Compound Sets
34
AdooQ Bioactive Compound Library
A13198
BOC Sciences Bioactive Compounds
tiagabine-cas-115103-54-3-item-84-55023
Cayman Chemical Bioactives
22926
30766
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1695
CHEMBL1027
ChEMBL Drugs
CHEMBL1695
CHEMBL1027
Concise Guide to Pharmacology 2017/18
4685
4818
Concise Guide to Pharmacology 2019/20
4685
4818
Concise Guide to Pharmacology 2021/22
4685
4818
Concise Guide to Pharmacology 2023/24
4685
4818
Drug Repurposing Hub
DrugBank
DB00906
DrugBank Approved Drugs
DB00906
DrugCentral
2648
DrugCentral Approved Drugs
2648
DrugMAP
DMKSQG0
DrugMAP Approved Drugs
DMKSQG0
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101241
Guide to Pharmacology
4685
4818
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1695
CHEMBL1027
Mcule NIBR MoA Box Subset
MCULE-2541016450
MedChem Express Bioactive Compound Library
HY-B0696A
NCATS Inxight Approved Drugs
Z80I64HMNP
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
tiagabine-hydrochloride
TargetMol Bioactive Compound Library
T7000
Tocris Bioactive Compound Library
4256
Tocriscreen Plus
4256
ZINC Tool Compounds
ZINC000003831531
External IDs
67
Properties
(calculated by RDKit )
Molecular Weight
375.13
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
5.04
TPSA
40.54
Fraction CSP3
0.45
Chiral centers
1.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Transporters
Target
GABA Receptor
GABA transporter 1
GABA uptake
SLC6A1
Pathway
Neuronal Signaling
Membrane Transporter/Ion Channel
Neuroscience
MOA
sodium- and chloride-dependent GABA transporter inhibitor
Inhibitor
GAT-1 Inhibitors
GABA uptake inhibitor
Primary Target
GABA Transporters
Member status
member
Indication
seizures
Therapeutic Class
Anticonvulsants
Source data