General
Preferred name
PARICALCITOL
Synonyms
Paricalcitol-D6 ()
Zemplar ()
COMPOUND-49510 ()
Compound 49510 ()
P&D ID
PD009651
CAS
131918-61-1
Tags
available
drug
Approved by
FDA
First approval
1998
Drug indication
Hyperparathyroidism
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Vitamin D receptor agonist (GtoPdb)
Cell lines
1
Organisms
0
Compound Sets
18
Cayman Chemical Bioactives
17716
ChEMBL Approved Drugs
CHEMBL1200622
ChEMBL Drugs
CHEMBL1200622
Drug Repurposing Hub
DrugBank
DB00910
DrugBank Approved Drugs
DB00910
DrugCentral
2066
DrugCentral Approved Drugs
2066
DrugMAP
DMYBV3G
DrugMAP Approved Drugs
DMYBV3G
Enamine BioReference Compounds
Guide to Pharmacology
2791
MedChem Express Bioactive Compound Library
HY-50919
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
6702D36OG5
Novartis Chemogenetic Library (NIBR MoA Box)
NURSA ligand set
nursa/index.jsf?doi=10.1621%2FHL2JKX6QVI
Other bioactive compounds
External IDs
47
Properties
(calculated by RDKit )
Molecular Weight
416.33
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
0
cLogP
5.56
TPSA
60.69
Fraction CSP3
0.78
Chiral centers
7.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
VD/VDR
VDR
Pathway
Vitamin D Related
Vitamin D Related/Nuclear Receptor
Member status
member
MOA
Cytochrome P450c24 (CYP24) Inhibitors
Cytochrome P450 CYP3A4 Inhibitors
Parathyroid Hormone Secretion Inhibitors
Signal Transduction Modulators
Vitamin D Receptor (VDR) Agonists
vitamin D receptor agonist
Indication
chronic kidney disease (CKD), hyperthyroidism
Disease Area
nephrology, endocrinology
Biosynthetic Origin
Terpenoid
Therapeutic Indication
Calcium Metabolism
Therapeutic Class
Hormone Therapy
Parasympathomimetics
Source data