General
Preferred name
AMANTADINE
Synonyms
AMANTADINE HYDROCHLORIDE ()
1-adamantanamine HCl ()
1-Adamantanamine hydrochloride ()
Symmetrel ()
CI-719 ()
Amantadine HCl ()
1-Adamantylamine hydrochloride ()
1-Aminoadamantane ()
1-Adamantanamine ()
1-Adamantylamine ()
Adamantamine fumarate ()
Symmetrel665-66-7 ()
Amantadine (hydrochloride) ()
1-Aminoadamantane hydrochloride ()
1-Adamantanamine, 1-Adamantylamine, 1-Aminoadamantane ()
adamantan-1-amine ()
Osmolex er ()
Mantadix ()
Symadine ()
Osmolex ()
Gocovri ()
Mantadine ()
Adamantanamine hydrochloride ()
EXP-105-1 ()
Lysovir ()
NSC-83653 ()
TCMDC-125869 ()
NSC-341865 ()
Amantadina ()
amantidine ()
P&D ID
PD009648
CAS
665-66-7
768-94-5
80789-67-9
102395-13-1
Tags
available
drug
Approved by
FDA
First approval
1968
Drug indication
Influenza A virus infection
infection
postencephalitic Parkinson disease
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti-orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6].
PRICE 29
DESCRIPTION Chemically amantidine has an adamantane backbone with an amino group substituted at one of the four methyne positions. Clinically it has antiviral (blocking the viral M2 proton channel) and antiparkinsonian actions.
DESCRIPTION Chemically amantadine has an adamantane backbone with an amino group substituted at one of the four methyne positions. Clinically it has antiviral (blocking the viral M2 proton channel) and antiparkinsonian actions. (GtoPdb)
PRICE 29
DESCRIPTION Dopamine releaser used in the treatment of Parkinsonism and drug-;related extrapyramidal reactions; antiviral (Influenza A) (LOPAC library)
DESCRIPTION Amantadine hydrochloride is an NMDA receptor antagonist. It is used for the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions. (Enamine Bioactive Compounds)
DESCRIPTION Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease. (TargetMol Bioactive Compound Library)
DESCRIPTION Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. (TargetMol Bioactive Compound Library)
DESCRIPTION Antiviral activity against Influenza A virus A/Puerto Rico/8/34 expressing wild type M2 proton channel infected in MDCK cells assessed as inhibition of viral replication measured after 10 hrs by miniplaque assay; Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligand (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
9
Compound Sets
32
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1569
CHEMBL660
ChEMBL Drugs
CHEMBL1569
CHEMBL660
Concise Guide to Pharmacology 2017/18
4128
Concise Guide to Pharmacology 2019/20
4128
Concise Guide to Pharmacology 2021/22
4128
Concise Guide to Pharmacology 2023/24
4128
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00915
DrugBank Approved Drugs
DB00915
DrugCentral
144
DrugCentral Approved Drugs
144
DrugMAP
DMS3YE9
DrugMAP Approved Drugs
DMS3YE9
DrugMatrix
Enamine Bioactive Compounds
EBC-00003
Enamine BioReference Compounds
Guide to Pharmacology
4128
Ki Database
Amantadine
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL660
MedChem Express Bioactive Compound Library
HY-B0402A
HY-B0402
NCATS Inxight Approved Drugs
BF4C9Z1J53
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
Amantadine-hydrochloride(Symmetrel)
amantadine
TargetMol Bioactive Compound Library
T1406
FF01-5992
T7060
The Spectrum Collection
External IDs
77
Properties
(calculated by RDKit )
Molecular Weight
151.14
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
0
cLogP
1.91
TPSA
26.02
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
6.0
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
viral matrix protein 2 inhibitor
Dopamine Receptor Agonists
NMDA Antagonists
M2 Channel Inhibitors
glutamate receptor antagonist
Target
Glutamate [NMDA] receptor
Matrix protein 2
dopamine
Influenza Virus
DRD2, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A
Apoptosis
Bcl-2 Family
CDK
Orthopoxvirus
SARS-CoV
Dopamine Receptor
Member status
virtual
Indication
influenza A virus infection, Parkinson's Disease
Disease Area
infectious disease, neurology/psychiatry
Therapeutic Class
Antiviral Agents
Pathway
Anti-infection
Cell Cycle/DNA Damage
GPCR/G protein
Microbiology/virology
Neuroscience
Source data