General
Preferred name
ACEPROMAZINE
Synonyms
ACEPROMAZINE MALEATE ()
Noctran ()
Acetopromazine maleate salt ()
Acetylpromazine ()
ACE ()
NSC-264522 ()
Atravet ()
Acezine 2 ()
Concentrat vo34 ()
Acepromazina ()
Acepromazine (maleate) ()
P&D ID
PD009645
CAS
61-00-7
3598-37-6
Tags
available
molecular glue
drug candidate
drug
Approved by
FDA
Drug Status
vet_approved
approved
experimental
investigational
Max Phase
2.0
Drug indication
Psychosis
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
61
DESCPRITION
A phenothiazine that is used in the treatment of PSYCHOSES.
DESCRIPTION
ACEPROMAZINE MALEATE is a dopamine receptor antagonist
(TargetMol Bioactive Compound Library)
DESCRIPTION
Acetylpromazine is a phenothiazine derivative. It has depressant effect on the central nervous system and is used in the treatment of psychoses. It is now almost exclusively used on animals as a sedative and antiemetic. It is used primarily as a chemical restraint in hyperactive or fractious animals. It acts as a dopamine receptor antagonist in the central nervous system, thus causing sedation, muscular relaxation and a reduction in spontaneous activity. It acts as an antagonist on different postsysnaptic receptors -on dopaminergic-receptors, on serotonergic-receptors, on histaminergic-receptors and so on. It has been listed.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
MolGlueDB
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
47
Molecular Weight
326.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
4.44
TPSA
23.55
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
dopamine
ADRA1A, ADRA1B, DRD1, DRD2, HTR1A, HTR2A
Indication
sedative
MOA
Dopamine Receptor antagonist
Pathway
GPCR/G protein
Neuroscience
Solubility
Soluble in DMSO, not in water
Source data
