General
Preferred name
DINOPROSTONE
Synonyms
Prostaglandin E2 ()
PGE2 ()
Prostaglandin E2 (PGE2) ()
Dinoprostone,Prepidil ()
Prostaglandin E2-d4 ()
Prostaglandin E2 MaxSpec® Standard ()
Prostaglandin E2-d4 MaxSpec® Standard ()
Prostaglandin E2-d9 ()
[3H]PGE2 ()
Prostaglandin e2 ()
NSC-165560 ()
U-12062 ()
Dinoprostona ()
Propess ()
NSC-196514 ()
Dinoprostone beta-Cyclodextrin Clathrate ()
Enzaprost e ()
U-12,062 ()
Prepidil ()
Cervidil ()
Prostin E2 ()
Minprostin e2 ()
P&D ID
PD009643
CAS
363-24-6
34210-10-1
1356347-42-6
Tags
available
drug
Approved by
PMDA
FDA
First approval
1977
Drug indication
Pain
Medical abortion
Drug Status
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.
PRICE 78
DESCRIPTION High affinity D1-like antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Major endogenous prostanoid (Tocriscreen Total)
DESCRIPTION Prostaglandin E2 is a naturally occurring COX product used as a medication in labor induction, bleeding after delivery, and termination of pregnancy. It directly targets muscle stem cells (MuSCs) via EP4 receptor, resulting in MuSC expansion. (BOC Sciences Bioactive Compounds)
DESCRIPTION Prostaglandin E2 (PGE2) is a naturally occurring hormone involved in various physiological processes, such as smooth muscle contraction and relaxation, vasodilation and constriction, blood pressure regulation, and inflammatory regulation. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
32
AdooQ Bioactive Compound Library
A11903
BOC Sciences Bioactive Compounds
prostaglandin-e2-cas-363-24-6-286161
Cayman Chemical Bioactives
10581
10007273
314010
10007211
14010
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL548
ChEMBL Drugs
CHEMBL548
Concise Guide to Pharmacology 2017/18
1883
1916
Concise Guide to Pharmacology 2019/20
1883
1916
Concise Guide to Pharmacology 2021/22
1883
1916
Concise Guide to Pharmacology 2023/24
1883
1916
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00917
DrugBank Approved Drugs
DB00917
DrugCentral
913
DrugCentral Approved Drugs
913
DrugMAP
DMTYOPD
DrugMAP Approved Drugs
DMTYOPD
EU-OPENSCREEN Bioactive Compound Library
EOS101721
Guide to Pharmacology
1883
1916
JUMP-Target 1 Compound Set
5280360
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL548
MedChem Express Bioactive Compound Library
HY-101952
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
prostaglandin-e2-cervidil
TargetMol Bioactive Compound Library
T5014
Tocris Bioactive Compound Library
2296
Tocriscreen Total
Withdrawn 2.0
w157
ZINC Tool Compounds
ZINC000003830713
External IDs
74
Properties
(calculated by RDKit )
Molecular Weight
352.22
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
12
Ring Count
1
Aromatic Ring Count
0
cLogP
3.25
TPSA
94.83
Fraction CSP3
0.7
Chiral centers
4.0
Largest ring
5.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
prostaglandin receptor agonist
Agonist
prostanoid receptor agonist
Target
Prostaglandin E2 receptor
Endogenous Metabolite
EP2
Human Endogenous Metabolite
Prostaglandin Receptor
CATSPER1, CATSPER2, CATSPER3, CATSPER4, PTGDR, PTGDR2, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, TBXA2R
CATSPER4
PGES,Prostaglandin Receptor
Organoid
Primary Target
Prostanoid Receptors
Member status
member
ATC
G02AD02
Toxicity type
muscular
Therapeutic Class
Prostaglandins
Pathway
GPCR/G protein
Metabolic Enzyme/Protease
Stem Cell/Wnt
Metabolism
Solubility
Soluble in DMSO.
Source data