General
Preferred name
KETOTIFEN
Synonyms
KETOTIFEN FUMARATE ()
Ketotifenum ()
HC 20511 fumarate ()
Ketotifen (fumarate) ()
HC 20-511 ()
ACUVUE THERAVISION WITH KETOTIFEN ()
ZADITOR ()
KETOTIFEN HYDROGEN FUMARATE ()
ZADITEN ()
ALAWAY ()
KETOTIFEN (AS FUMARATE) ()
HC 20,511 FUMARATE ()
HC-20511 FUMARATE ()
CHILDREN'S ALAWAY ()
NSC-757415 ()
Ketotifene ()
(R)-Ketotifen ()
Ketotifeno ()
Ketotifen-13C-d3 ()
P&D ID
PD009641
CAS
34580-14-8
116655-74-4
34580-13-7
126939-14-8
2748522-40-7
Tags
available
prodrug
drug
Approved by
FDA
First approval
1999
Drug indication
Fibromyalgia
Allergic conjunctivitis
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention[1][2][3][4].
PRICE 29
DESCRIPTION Ketotifen is an antihistamine. This drug may be used in eye drop or oral formulations, where the active ingredient is ketotifen fumarate (PubChem CID 5282408). (GtoPdb)
DESCRIPTION Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention[1][2][3][4].
DESCRIPTION H1 Histamine receptor antagonist (LOPAC library)
DESCRIPTION H1 antagonist (Tocriscreen Total)
DESCRIPTION alpha2 agonist. Also I1 ligand (Tocris Bioactive Compound Library)
DESCRIPTION Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
5
Compound Sets
28
Cayman Chemical Bioactives
20303
28802
ChEMBL Approved Drugs
CHEMBL1633
CHEMBL534
ChEMBL Drugs
CHEMBL1633
CHEMBL534
DrugBank
DB00920
DrugBank Approved Drugs
DB00920
DrugCentral
1530
DrugCentral Approved Drugs
1530
DrugMAP
DMOVY05
DrugMAP Approved Drugs
DMOVY05
DrugMatrix
EUbOPEN Chemogenomics Library
EUB0000489
Guide to Pharmacology
7206
Ki Database
KETOTIFEN
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1633
CHEMBL534
MedChem Express Bioactive Compound Library
HY-B0157A
HY-B0157
NCATS Inxight Approved Drugs
X49220T18G
NIH Clinical Collections (NCC)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
ketotifen-fumarate-zaditor
TargetMol Bioactive Compound Library
T0994
The Spectrum Collection
Tocris Bioactive Compound Library
0784
Tocriscreen Total
ZINC Tool Compounds
ZINC000000004351
External IDs
70
Properties
(calculated by RDKit )
Molecular Weight
309.12
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
4.01
TPSA
20.31
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
7.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H1
Pathway
GPCR/G protein
Immunology/Inflammation
Metabolism
Neuroscience
Anti-infection
Metabolic Enzyme/Protease
Neuronal Signaling
Primary Target
Histamine H1 Receptors
MOA
Antagonist
Target
Endogenous Metabolite
Histamine Receptor
Influenza Virus
SARS-CoV
H1 receptor
PDE
Therapeutic Class
Antiallergic Agents
Recommended Cell Concentration
10 nM
Source data