General
Preferred name
MESORIDAZINE
Synonyms
MESORIDAZINE BESYLATE ()
10-(2-(1-Methyl-2-piperidinyl)ethyl)-2-(methylsulfinyl)phenothiazine ()
Mesoridazine benzenesulfonate ()
Serentil ()
Mesoridazine ()
TPS-23 ()
Mesoridazine besilate ()
NSC-760073 ()
Mesoridazina ()
NC-123 ()
Thioridazine-2-sulfoxide ()
Lidanar ()
NSC-186066 ()
P&D ID
PD009634
CAS
5588-33-0
32672-69-8
Tags
available
drug
Approved by
FDA
First approval
1970
Drug indication
Schizophrenia
Psychosis
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
139
DESCRIPTION
The approved drug contains a racemic mixture of enantiomers . The four possible isomers are depicted in PubChem CID 76960490. We show the non-isomeric molecule to represent this mixture.
(GtoPdb)
DESCRIPTION
Mesoridazine (TPS-23) , a metabolite of Thioridazine (HY-B0965A), acts as an orally active phenothiazine antipsychotic agent. Mesoridazine is a potent and rapid open-channel blocker of human ether-a-go-go related gene (hERG) channels and blocks hERG currents with an IC50 of 550 nM (at 0 mV) in human embryonic kidney 293 cells[1].Mesoridazine can be used for the research of schizophrenia, as well as certain other psychiatric disorders[1][2].
DESCRIPTION
Mesoridazine Besylate (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Mesoridazine is a phenothiazine antipsychotic that binds to histamine H1, dopamine D2, muscarinic acetylcholine, and α1- and α2-adrenergic receptors (Kds = 1.8, 19, 69, 2, and 1,600 nM, respectively).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
22
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
Ki Database
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
51
Molecular Weight
386.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
4.9
TPSA
23.55
Fraction CSP3
0.43
Chiral centers
2.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT
dopamine
Potassium Channel
ATC
N05AC03
Therapeutic Class
Antipsychotic Agents
Pathway
Membrane Transporter/Ion Channel
GPCR/G protein
Neuroscience
Source data
