General
Preferred name
phenprocoumon
Synonyms
Phenprocoumon(Marcumar) ()
Marcoumar, Marcumar and Falithrom,Ro 1-4849 ()
Phenprocumone ()
Marcoumar ()
Fenprocumon ()
Phenprocoumarole ()
Liquamar ()
Phenprocoumarol ()
BS-7565 ()
Phenprocoumone ()
Marcumar ()
Fencumar ()
RO-1-4849 ()
P&D ID
PD009625
CAS
435-97-2
53621-47-9
Tags
available
drug
Approved by
FDA
First approval
1957
Drug indication
Recurrent thrombophlebitis
Thrombosis
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Phenprocoumon is a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K.
PRICE
29
DESCRIPTION
Phenprocoumon is an antagonist of vitamin K(IC50:1 ??M).
DESCRIPTION
Vitamin K epoxide reductase complex subunit 1 isoform 1 inhibitor. The INN-designated compound is a racemic mixture of two enantiomers.The structure shown here does not specify stereochemistry and represents the mixture.
(GtoPdb)
DESCRIPTION
Phenprocoumon inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K. Phenprocoumon used for the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation.
(Enamine Bioactive Compounds)
DESCRIPTION
Phenprocoumon is an antagonist of vitamin K(IC50:1 μM).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
20
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
280.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
4.04
TPSA
50.44
Fraction CSP3
0.17
Chiral centers
1.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
vitamin K epoxide reductase inhibitor
Target
Vitamin k epoxide reductase complex subunit 1 isoform 1
vitamin K
VD/VDR
5-alpha Reductase
ATC
B01AA04
Therapeutic Class
Anticoagulants
Pathway
Vitamin D Related/Nuclear Receptor
Source data
