General
Preferred name
NARATRIPTAN
Synonyms
GR-85548A D3 ()
GR-85548A ()
Naratriptan (D3 Hydrochloride) ()
GR-85548A hydrochloride ()
Naratriptan HCl ()
Amerge ()
Naramig ()
NARATRIPTAN HYDROCHLORIDE ()
Naratriptan (hydrochloride) ()
GR 85548A ()
Naratriptan ()
P&D ID
PD009622
CAS
143388-64-1
121679-13-8
Tags
natural product
drug
available
Approved by
FDA
First approval
1998
Drug Status
investigational
approved
Drug indication
Migraine
Antimigraine
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Marketed formulations may contain naratriptan hydrochloride (PubChem CID 60875). (GtoPdb)
DESCRIPTION Naratriptan, a 5-HT1B/1D receptor agonist, could be used in the treatment of migraine. (BOC Sciences Bioactive Compounds)
Compound Sets
27
BOC Sciences Bioactive Compounds
naratriptan-cas-121679-13-8-item-55827
Cayman Chemical Bioactives
23754
ChEMBL Approved Drugs
CHEMBL1200601
CHEMBL1278
ChEMBL Drugs
CHEMBL1200601
CHEMBL1278
Concise Guide to Pharmacology 2017/18
45
Concise Guide to Pharmacology 2019/20
45
Concise Guide to Pharmacology 2021/22
45
Concise Guide to Pharmacology 2023/24
45
Drug Repurposing Hub
DrugBank
DB00952
DrugBank Approved Drugs
DB00952
DrugCentral
1884
DrugCentral Approved Drugs
1884
DrugMAP
DMO50U2
DrugMAP Approved Drugs
DMO50U2
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS101235
Guide to Pharmacology
45
Ki Database
Naratriptan
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1278
MedChem Express Bioactive Compound Library
HY-B0197A
NCATS Inxight Approved Drugs
QX3KXL1ZA2
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
Naratriptan(Amerge)
TargetMol Bioactive Compound Library
T6602
External IDs
60
Properties
(calculated by RDKit )
Molecular Weight
335.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
2.07
TPSA
65.2
Fraction CSP3
0.53
Chiral centers
0.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT Receptor
5-HT1
HTR1A, HTR1B, HTR1D, HTR1E, HTR1F
Pathway
Neuronal Signaling
GPCR/G protein
Neuroscience
Indication
migraine headache
MOA
serotonin receptor agonist
Therapeutic Class
Vasoconstrictor Agents
Solubility
DMSO 74 mg/mL (198 mM)
Water 22 mg/mL (59 mM)
Source data