General
Preferred name
RIZATRIPTAN
Synonyms
RIZATRIPTAN BENZOATE ()
MK-462 Benzoate ()
Rizatriptan (benzoate) ()
RIZATRIPTAN SULFATE ()
MK 462 ()
Maxalt ()
NSC-758919 ()
MK-0462 ()
Maxalt-Mlt ()
MK-462 FREE BASE ()
MK-462 ()
L-705126 ()
Rizatriptan sulfate hydrate ()
MK-A462 ()
Rizatriptan sulphate ()
Rizatriptan (benzoate salt) ()
Rizatriptan-d6 (benzoate salt) ()
P&D ID
PD009621
CAS
145202-66-0
144034-80-0
1216984-85-8
Tags
drug candidate
natural product
drug
available
Approved by
FDA
First approval
1998
Drug Status
approved
Drug indication
Migraine
Antimigraine
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Rizatriptan is a triptan 5-HT1 receptor agonist anti-migraine drug. (GtoPdb)
DESCRIPTION AT1 antagonist; PPARgamma partial agonist (Tocris Bioactive Compound Library)
DESCRIPTION Potent 5-HT1B/1D agonist (Tocriscreen Plus)
Cell lines
0
Organisms
1
Compound Sets
31
Cayman Chemical Bioactives
16475
33369
ChEMBL Approved Drugs
CHEMBL1201032
CHEMBL905
ChEMBL Drugs
CHEMBL1201032
CHEMBL905
CHEMBL3989629
Concise Guide to Pharmacology 2017/18
51
Concise Guide to Pharmacology 2019/20
51
Concise Guide to Pharmacology 2021/22
51
Concise Guide to Pharmacology 2023/24
51
Drug Repurposing Hub
DrugBank
DB00953
DrugBank Approved Drugs
DB00953
DrugCentral
2393
DrugCentral Approved Drugs
2393
DrugMAP
DMDJMA3
DrugMAP Approved Drugs
DMDJMA3
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS102452
Guide to Pharmacology
51
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL905
MedChem Express Bioactive Compound Library
HY-B0206
NCATS Inxight Approved Drugs
51086HBW8G
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Rizatriptan-Benzoate(Maxalt)
TargetMol Bioactive Compound Library
T1512
The Spectrum Collection
Tocris Bioactive Compound Library
5136
Tocriscreen Plus
5136
External IDs
63
Properties
(calculated by RDKit )
Molecular Weight
269.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
1.91
TPSA
49.74
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
5-HT
HTR1A, HTR1B, HTR1D, HTR1E, HTR1F
5-HT Receptor
Primary Target
5-HT1B Receptors
MOA
5-HT Receptor antagonist
Agonist
5-HT1B Agonists
5-HT1D Agonists
serotonin receptor agonist
Member status
member
Indication
migraine headache
Therapeutic Class
Antiinflammatory Agents
Source data