General
Preferred name
MEPIVACAINE
Synonyms
MEPIVACAINE HYDROCHLORIDE ()
Mepivacaine HCl ()
Carbocaine ()
Mepivacaine (hydrochloride) ()
Polocaine-Mpf ()
Mepivacaine monohydrochloride ()
Scandicain ()
Scandonest Plain ()
Scandicaine ()
Isocaine hydrochloride ()
Polocaine ()
Scandonest ()
Arestocaine hydrochloride ()
Optocain ()
NSC-758674 ()
Mepisv ()
1-methyl-2',6'-pipecoloxylidide ()
APF-135 ()
Dl-mepivacaine ()
Mepivacaina ()
Tevacaine ()
Carboplyin dental ()
2',6'-pipecoloxylidide, 1-methyl- ()
Mepivacaine-d3 ()
P&D ID
PD009616
CAS
1722-62-9
22801-44-1
34811-66-0
96-88-8
16452-56-5
1346597-90-7
Tags
available
drug
Approved by
PMDA
FDA
First approval
1960
Drug indication
Pain
Analgesia
Drug Status
vet_approved
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
PHARMACODYNAMICS Mepivicaine is an amide local anesthetic. Mepivicaine as a reasonably rapid onset and medium duration and is known by the proprietary names as Carbocaine and Polocaine. Mepivicaine is used in local infiltration and regional anesthesia. Systemic absorption of local anesthetics produces effects on the cardiovascular and central nervous systems. At blood concentrations achieved with normal therapeutic doses, changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance are minimal.
DESCRIPTION Mepivacaine is an amide class local anesthetic. It is a racemic mixture of enantiomers. We show the chemical structure without specified stereochemistry to represent the mixture. (GtoPdb)
DESCRIPTION Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization[1][2].
PRICE 29
DESCRIPTION Mepivacaine is a tertiary amine used as a local anesthetic. (BOC Sciences Bioactive Compounds)
DESCRIPTION Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties. (TargetMol Bioactive Compound Library)
DESCRIPTION Mepivacaine is an amide-type local anesthetic agent. It binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. It is indicated for production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks. (Enamine Bioactive Compounds)
DESCRIPTION Mepivacaine (Carbocaine) is an amide compound for local anaesthesia that causes transient loss of self-consciousness in humans or animals. mepivacaine acts by binding to specific voltage-gated sodium channels in nerve cell membranes, inhibiting sodium inward flow and membrane depolarisation. mepivacaine is indicated for nerve blocks and epidurals. (TargetMol Bioactive Compound Library)
Compound Sets
22
BOC Sciences Bioactive Compounds
mepivacaine-hcl-cas-1722-62-9-item-84-185004
Cayman Chemical Bioactives
23402
39812
ChEMBL Approved Drugs
CHEMBL1200440
CHEMBL1087
ChEMBL Drugs
CHEMBL1200440
CHEMBL1087
DrugBank
DB00961
DrugBank Approved Drugs
DB00961
DrugCentral
1700
DrugCentral Approved Drugs
1700
DrugMAP
DMH2NMY
DrugMAP Approved Drugs
DMH2NMY
DrugMatrix
Enamine Bioactive Compounds
EBC-04411
Enamine BioReference Compounds
Guide to Pharmacology
7224
MedChem Express Bioactive Compound Library
HY-B0517A
HY-B0517
NCATS Inxight Approved Drugs
B6E06QE59J
NIH Clinical Collections (NCC)
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
mepivacaine-hydrochloride
mepivacaine
TargetMol Bioactive Compound Library
T0946
T22361
The Spectrum Collection
External IDs
67
Properties
(calculated by RDKit )
Molecular Weight
246.17
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
2.73
TPSA
32.34
Fraction CSP3
0.53
Chiral centers
1.0
Largest ring
6.0
QED
0.87
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Sodium Channel
Therapeutic Class
Anesthetics
Pathway
Membrane Transporter/Ion Channel
Source data