General
Preferred name
APRACLONIDINE
Synonyms
p-Aminoclonidine hydrochloride ()
Aminoclonidine, p ()
p-AMINOCLONIDINE ()
Iopidine ()
ALO 2145 ()
Apraclonidina ()
4-Aminoclonidine ()
Apraclonidine HCl ()
Apraclonidinum ()
Pharmaprojects No. 1758 ()
Apraclonidine (hydrochloride) ()
Iopidine HCl,ALO 2145 ()
APRACLONIDINE HYDROCHLORIDE ()
Aplonidine hydrochloride ()
AL02145 ()
AL-02145 ()
P&D ID
PD009614
CAS
66711-21-5
73218-79-8
Tags
available
drug
Approved by
FDA
First approval
1987
Drug indication
Myasthenia gravis
Intra ocular pressure reduction
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Apraclonidine (para-amino clonidine) is a derivative which acts as sympathomimetic α2-adrenoceptor agonist. (GtoPdb)
DESCRIPTION Apraclonidine hydrochloride (ALO 2145), a selective ¦Á2 and weak ¦Á1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid[1][2].
PRICE 36
DESCRIPTION Apraclonidine hydrochloride (ALO 2145) is an ??2-adrenergic agonist and a weak ??-1 adrenergic receptor agonist. Apraclonidine hydrochloride lowers intraocular pressure in human eyes and can be used in studies about glaucoma therapy.
DESCRIPTION Apraclonidine is a clonidine derivative with relatively selective alpha-2-adrenergic agonistic activity. It is an α2 adrenergic receptor agonist and a weak α1 adrenergic receptor agonist. It enhances aqueous humor uveoscleral outflow and decreases aqueous production by vasoconstriction. It is a sympathomimetic used in glaucoma therapy. It was developed by Alcon and has been listed. (BOC Sciences Bioactive Compounds)
DESCRIPTION alpha2 Adrenoceptor agonist (LOPAC library)
DESCRIPTION Apraclonidine is an α2-adrenergic receptor (α2-AR) agonist and structural analog of clonidine. It is used for the treatment of post-surgical elevated intraocular pressure. It inhibits noradrenaline-stimulated contraction in guinea pig ileum with EC50s of 7.59 nM and rabbit vas deferens with EC50s of 6.76 nM. (BOC Sciences Bioactive Compounds)
DESCRIPTION Apraclonidine hydrochloride (ALO 2145) is an α2-adrenergic agonist and a weak α-1 adrenergic receptor agonist. Apraclonidine hydrochloride lowers intraocular pressure in human eyes and can be used in studies about glaucoma therapy. (TargetMol Bioactive Compound Library)
Compound Sets
29
BOC Sciences Bioactive Compounds
apraclonidine-cas-66711-21-5-item-96631
apraclonidine-hydrochloride-cas-73218-79-8-item-76067
Cayman Chemical Bioactives
23904
ChEMBL Approved Drugs
CHEMBL647
CHEMBL1200379
ChEMBL Drugs
CHEMBL647
CHEMBL1200379
Concise Guide to Pharmacology 2017/18
7117
Concise Guide to Pharmacology 2019/20
7117
Concise Guide to Pharmacology 2021/22
7117
Concise Guide to Pharmacology 2023/24
7117
Drug Repurposing Hub
DrugBank
DB00964
DrugBank Approved Drugs
DB00964
DrugCentral
229
DrugCentral Approved Drugs
229
DrugMAP
DMO4PVE
DrugMAP Approved Drugs
DMO4PVE
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS102449
Guide to Pharmacology
7117
Ki Database
Aminoclonidine, p
p-AMINOCLONIDINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL647
Mcule NIBR MoA Box Subset
MCULE-7993920296
MedChem Express Bioactive Compound Library
HY-12720A
NCATS Inxight Approved Drugs
843CEN85DI
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
apraclonidine-hcl
TargetMol Bioactive Compound Library
T21371
ZINC Tool Compounds
ZINC000000020231
External IDs
54
Properties
(calculated by RDKit )
Molecular Weight
244.03
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
1.95
TPSA
62.44
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha2
Target
α2-adrenoceptor
ADRA1A, ADRA2A, ADRA2B, ADRA2C
Adrenergic Receptor
Member status
member
MOA
alpha2-Adrenoceptor Agonists
Adrenergic Receptor agonist
Indication
glaucoma, intraocular pressure
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Therapeutic Class
Antiglaucomic Agents
Solubility
Soluble in DMSO, ethanol, methanol.
Soluble in DMSO, not in water
Source data