General
Preferred name
LOMEFLOXACIN
Synonyms
LOMEFLOXACIN HYDROCHLORIDE ()
Lomefloxacin HCl ()
Okacyn ()
Maxaquin ()
SC47111A ()
Lomefloxacin ()
Lomefloxacin (hydrochloride) ()
SC47111A (hydrochloride) ()
NY-198 (hydrochloride) ()
LOMEFLOXACIN MESYLATE ()
Lomefloxacin (as hydrochloride) ()
NY-198 ()
NSC-758168 ()
Lomefloxacin monohydrochloride ()
SC-47111 ()
Lomefloxacino ()
Lomefloxacine ()
SC-47111A ()
SC-47111B ()
Lomefloxacin mesilate ()
P&D ID
PD009609
CAS
98079-51-7
98079-52-8
114394-67-1
Tags
available
drug
drug candidate
Approved by
FDA
First approval
1992
Drug indication
osteomyelitis
Bacterial infection
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Lomefloxacin is a fluoroquinolone antibacterial compound with activity against both Gram-negative and Gram-positive bacteria . (GtoPdb)
PRICE 29
DESCRIPTION DNA gyrase inhibitor (LOPAC library)
DESCRIPTION Lomefloxacin hydrochloride (Okacyn) inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhibition leads to a decrease in DNA synthesis during bacterial replication, resulting in cell growth inhibition and eventually cell lysis. Lomefloxacin Hydrochloride is the hydrochloride salt form of lomefloxacin, a synthetic broad-spectrum fluoroquinolone with antibacterial activity. (TargetMol Bioactive Compound Library)
DESCRIPTION Lomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms, which is commonly used to treat bacterial infections, including bronchitis and urinary tract infections. It is used as a pre-operative prophylactic to prevent urinary tract infection caused by S. pneumoniae, H. influenzae, S. aureus, P. aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E. coli, and K. pneumoniae. It is used to induce genomic instability in mice1 and modification of the kinetics of growth of Gram-negative bacteria. It inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. (BOC Sciences Bioactive Compounds)
DESCRIPTION Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
22
BOC Sciences Bioactive Compounds
lomefloxacin-cas-98079-51-7-item-84-80366
Cayman Chemical Bioactives
28271
ChEMBL Approved Drugs
CHEMBL1728
CHEMBL561
ChEMBL Drugs
CHEMBL1728
CHEMBL561
CHEMBL2106827
DrugBank
DB00978
DrugBank Approved Drugs
DB00978
DrugCentral
1594
DrugCentral Approved Drugs
1594
DrugMAP
DMVRH9C
DrugMAP Approved Drugs
DMVRH9C
DrugMatrix
Guide to Pharmacology
12407
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0455
NPC Screening Collection
Pandemic Response Box
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Lomefloxacin-hydrochloride-Maxaquin
lomefloxacin
TargetMol Bioactive Compound Library
T1625
T1444
The Spectrum Collection
Withdrawn 2.0
665
External IDs
64
Properties
(calculated by RDKit )
Molecular Weight
351.14
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
1.8
TPSA
74.57
Fraction CSP3
0.41
Chiral centers
1.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
DNA Gyrase
Pathway
Anti-infection
DNA Damage/DNA Repair
Microbiology/virology
Cell Cycle/DNA Damage
Immunology/Inflammation
Metabolic Enzyme/Protease
NF-κB
Target
antibiotic
Bacterial
Topo II
Topo IV
Apoptosis
Reactive Oxygen Species (ROS)
Topoisomerase
Antibiotics,Bacterial
MOA
Topoisomerase inhibitor
ATC
J01MA07
S01AE04
Therapeutic Class
Antibiotics
Source data