General
Preferred name
framycetin
Synonyms
Vibrocil ()
Tribiotic ()
Cicatrin ()
Biomydrin ()
Naseptin ()
Myciguent ()
Cicatrene ()
Graneodin ()
Neosporin ()
Nivemycin ()
Neobacrin ()
Gppe Nsl Gel ()
neomycin ()
Framycetin sulphate ()
Framycin sulfate ()
Neomycin Sulphate B ()
NEOMYCIN SULFATE ()
Framycetin (sulfate) ()
Neomycin (sulfate) ()
Neomycin B (sulfate) ()
Fradiomycin B (sulfate) ()
Dekamycin iii ()
Enterfram ()
Framidal ()
Fradiomycin B ()
Neomycin B ()
ANTIBIOTIQUE EF 185 ()
Framygen ()
Antibiotic 10676 ()
Francetin ()
Framycin ()
Actilin ()
P&D ID
PD009601
CAS
4146-30-9
1405-10-3
28002-70-2
11025-81-3
119-04-0
Tags
drug
natural product
biased GPCR ligand
available
Drug Status
investigational
approved
Drug indication
Antibacterial,Antifungal
Acute liver failure
Bacterial infection
Alcoholic cirrhosis of liver
Antibacterial
Max Phase
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Neomycin is an aminoglycoside antibacterial. Neomycin is active against Gram-negative bacteria, and partially active against Gram-positive bacteria. Standard grade neomycin is a mixture of several related compounds, including neomycin A (neamine), neomycin B (framycetin) and neomycin C, with neomycin B being the most active component. We show the structure of neomycin B here. (GtoPdb)
Cell lines
0
Organisms
2
Compound Sets
17
BiasDB
Framycetin
Cayman Chemical Bioactives
14287
ChEMBL Drugs
CHEMBL184618
Drug Repurposing Hub
DrugBank
DB00452
DrugBank Approved Drugs
DB00452
DrugCentral
1896
DrugCentral Approved Drugs
1896
DrugMAP
DMF8DNE
DrugMAP Approved Drugs
DMF8DNE
Guide to Pharmacology
709
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL184618
MedChem Express Bioactive Compound Library
HY-17624A
HY-B0470
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
T2096
T0950
External IDs
66
Properties
(calculated by RDKit )
Molecular Weight
614.31
Hydrogen Bond Acceptors
19
Hydrogen Bond Donors
13
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
0
cLogP
-8.9
TPSA
353.11
Fraction CSP3
1.0
Chiral centers
19.0
Largest ring
6.0
QED
0.11
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Calcium Channel
Bacterial
antibiotic
30S ribosome
CXCR4
Phospholipase
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Anti-infection
Microbiology&virology
Metabolic Enzyme/Protease
MOA
Antibiotic inhibitor
ribosome inhibitor
bacterial 30S ribosomal subunit inhibitor
Indication
first-aid antibiotic, hepatic encephalopathy (HE), intra-abdominal infections
Disease Area
infectious disease, gastroenterology
Therapeutic Class
Antibiotics
Source data