General
Preferred name
framycetin
Synonyms
Vibrocil ()
Tribiotic ()
Cicatrin ()
Biomydrin ()
Naseptin ()
Myciguent ()
Cicatrene ()
Graneodin ()
Neosporin ()
Nivemycin ()
Neobacrin ()
Gppe Nsl Gel ()
neomycin ()
Neomycin Sulphate B ()
Framycetin sulphate ()
Framycin sulfate ()
NEOMYCIN SULFATE ()
Framycetin (sulfate) ()
Neomycin (sulfate) ()
Neomycin B (sulfate) ()
Fradiomycin B (sulfate) ()
Framycetin sulfate ()
Actilin ()
Francetin ()
ANTIBIOTIQUE EF 185 ()
Fradiomycin B ()
Framycetine ()
Antibiotic 10676 ()
Neomycin B ()
Framicetina ()
Dekamycin iii ()
Framidal ()
Framygen ()
Enterfram ()
Framycin ()
P&D ID
PD009601
CAS
28002-70-2
1405-10-3
11025-81-3
119-04-0
4146-30-9
Tags
available
drug
natural product
biased GPCR ligand
Drug indication
Acute liver failure
Bacterial infection
Alcoholic cirrhosis of liver
Nasal congestion
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 32
DESCRIPTION Neomycin is an aminoglycoside antibacterial. Neomycin is active against Gram-negative bacteria, and partially active against Gram-positive bacteria. Standard grade neomycin is a mixture of several related compounds, including neomycin A (neamine), neomycin B (framycetin) and neomycin C, with neomycin B being the most active component. We show the structure of neomycin B here. (GtoPdb)
DESCRIPTION Framycetin sulfate (Neomycin Sulphate B) belongs to aminoglycoside class of antibiotics that contain two or more aminosugars connected by glycosidic bonds. (TargetMol Bioactive Compound Library)
DESCRIPTION Neomycin sulfate (Framycin sulfate) is a broad-spectrum aminoglycoside antibiotic that blocks the synthesis of bacterial proteins in order to exert antimicrobial activity. Neomycin sulfate is commonly used to screen prokaryotic and eukaryotic cells for Neo resistance genes. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
17
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
External IDs
73
Properties
(calculated by RDKit )
Molecular Weight
614.31
Hydrogen Bond Acceptors
19
Hydrogen Bond Donors
13
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
0
cLogP
-8.9
TPSA
353.11
Fraction CSP3
1.0
Chiral centers
19.0
Largest ring
6.0
QED
0.11
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Calcium Channel
Bacterial
antibiotic
30S ribosome
Phospholipase
CXCR4
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Anti-infection
Microbiology/virology
Metabolism
Metabolic Enzyme/Protease
MOA
Antibiotic inhibitor
ribosome inhibitor
bacterial 30S ribosomal subunit inhibitor
Indication
first-aid antibiotic, hepatic encephalopathy (HE), intra-abdominal infections
Disease Area
infectious disease, gastroenterology
Therapeutic Class
Antibiotics
Source data