General
Preferred name
cromoglicic acid
Synonyms
CROMOLYN SODIUM ()
CROMOLYN ()
FPL-670 ()
Disodium Cromoglycate ()
FPL 670 (Cromolyn) Disodium ()
Sodium cromoglycate ()
Sodium Cromoglicate ()
Cromolyn disodium salt ()
Cromoglicate ()
Cromolyn (sodium) ()
Gynazole ,FPL 670 (Cromolyn) Disodium,Cromolyn sodium ()
Sodium cromolyn ()
Vivicrom ()
Cromogen ()
Steri-Neb Cromogen ()
NSC-109500 ()
Nasalcrom ()
Cromoptic ()
Clariteyes ()
Intal 5 ()
Rynacrom Allergy ()
Eye-Crom ()
Rynacrom Co ()
Catacrom ()
Aerocrom ()
Aspire ()
FPL.670 ()
Cromoglicate sodium ()
Resiston Treatment Pack ()
Cromosol Optha ()
Intal ()
Nalcrom ()
Disodium cromolyn ()
Rynacrom ()
Opticrom ()
Vividrin ()
Gppe Syncroner Inha ()
Dominion Pharma Hayfever ()
Cromolux ()
Lomusol ()
Viz-On ()
Cusilyn ()
Hay-Crom ()
Astilyn ()
Lomudal ()
Crolom ()
Opticrom Aq ()
Glycavent ()
Murine ()
Cromosol ()
Cromolyn ()
Gastrocrom ()
Allercrom ()
Cromoglycic Acid ()
Cromogen E-Breathe ()
Natrii cromoglicas ()
Brol-Eze ()
Resiston One ()
Cromoglicic Acid ()
Cromo-comod ()
Cromoglycate ()
R03BC01 ()
Cromolyn (sodium salt hydrate) ()
P&D ID
PD009596
CAS
15826-37-6
16110-51-3
105878-73-7
Tags
natural product
drug
available
Approved by
FDA
First approval
1982
Drug Status
approved
Drug indication
Allergic rhinitis
Anti-Asthmatic (prophylactic)
Asthma
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cromoglicic acid is regarded as a mast cell stabilising drug, although its exact mechanism of action appears to be much more complicated. Clinical use in asthma has largely been replaced by the more convenient leukotriene receptor antagonists.
DESCRIPTION
Cromoglicic acid (cromolyn) is regarded as a mast cell stabilising drug, although its exact mechanism of action appears to be much more complicated.
Recent reports suggest that cromolyn inhibits glycogen synthase kinase 3β and may therefore have potential to treat diabetes and obesity and may prove effective in treating insulin-induced lipoatrophy . It also has reported potential anti-fibrotic action through agonism of GPR35 . (GtoPdb)
Recent reports suggest that cromolyn inhibits glycogen synthase kinase 3β and may therefore have potential to treat diabetes and obesity and may prove effective in treating insulin-induced lipoatrophy . It also has reported potential anti-fibrotic action through agonism of GPR35 . (GtoPdb)
DESCRIPTION
NLRP3 inhibitor; active in vivo
(Tocris Bioactive Compound Library)
DESCRIPTION
Cromolyn, a chromene derivative, could be used in the treatmen of allergic an a aast cell stabiliser.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Disodium Cromoglycate is an antiallergic drug with IC50 of 39 μg/mL.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
29
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
81
Molecular Weight
468.07
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
4
cLogP
2.11
TPSA
173.71
Fraction CSP3
0.13
Chiral centers
0.0
Largest ring
6.0
QED
0.35
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
PI3K/Akt/mTOR
Stem Cell/Wnt
Target
Protein S100-P
Potassium Channel
KCNMA1, S100P
Calcium Channel
GSK-3
Primary Target
ESCs and iPSCs
MOA
Others inhibitor
Potassium Channel inhibitor
Mediator Release Inhibitors
Immunosuppressant
Member status
member
Indication
asthma, conjunctivitis, urticaria, ulcerative colitis
Disease Area
pulmonary, ophthalmology, allergy, gastroenterology
Therapeutic Class
Antiasthmatic Agents
Source data
