General
Preferred name
MINOCYCLINE
Synonyms
MINOCYCLINE HYDROCHLORIDE ()
Minocycline HCl ()
Minocycline, Hydrochloride ()
Minocycline (hydrochloride) ()
Minocin ()
Minocycline (CL 59806) HCl ()
Minocycline (hydrochloride hydrate) ()
Minogal ()
Sebren MR ()
Minocin 50 ()
Arestin ()
Dynacin ()
Minocin MR ()
Solodyn ()
Minolira ()
Dentomycin ()
Acnamino ()
NSC-141993 ()
Blemix 100 ()
Aknemin 50 ()
Sebomin ()
Zilxi ()
Amzeeq ()
Blemix 50 ()
Minocycline (as hydrochloride) ()
Ximino ()
Cyclomin ()
Aknemin ()
Minociclina ()
P&D ID
PD009592
CAS
13614-98-7
10118-90-8
Tags
available
drug
Approved by
FDA
First approval
1971
Drug Status
approved
investigational
Max Phase
4.0
Drug indication
infection
periodontitis
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1¦Á inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect[1][2][3][4][5][6][7].
PRICE
29
PHARMACODYNAMICS
Minocycline, the most lipid soluble and most active tetracycline antibiotic, is, like doxycycline, a long-acting tetracycline. Minocycline's effects are related to the inhibition of protein synthesis. In particular, the broad spectrum of activity that minocycline generally possesses means it also demonstrates activity against Neisseria meningitidis. However, the agent is no longer recommended to be employed as prophylaxis as it is capable of eliciting problematic adverse effects like dizziness and vertigo. Current research is examining the possible neuroprotective effects of minocycline against progression of Huntington's Disease, an inherited neurodegenerative disorder. The neuroprotective action of minocycline may include its inhibitory effect on 5-lipoxygenase, an inflammatory enzyme associated with brain aging.
DESCRIPTION
5-HT and NA reuptake inhibitor (SNRI)
(Tocris Bioactive Compound Library)
DESCRIPTION
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochloride can cause both an acute hepatitis-like syndrome occurring within 1 to 3 months of starting therapy or a more insidious chronic hepatitis with autoimmune features typically after long-term treatment.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
9
Compound Sets
20
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
72
Molecular Weight
457.18
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
5
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
1
cLogP
0.19
TPSA
164.63
Fraction CSP3
0.43
Chiral centers
4.0
Largest ring
6.0
QED
0.4
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
Apoptosis
Calcium Channel
HIF/HIF Prolyl-Hydroxylase
MDM-2/p53
Potassium Channel
Primary Target
Antibiotics
MOA
Antibiotic
Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors
30S Ribosomal Protein Inhibitors
Protein Arginine Deiminase Inhibitors
Member status
member
Pathway
Chromatin/Epigenetic
Metabolism
Microbiology/virology
Anti-infection
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Neuronal Signaling
Source data
