General
Preferred name
PROCAINAMIDE
Synonyms
PROCAINAMIDE HYDROCHLORIDE ()
Procapan ()
Procainamide HCl ()
Pronestyl ()
Procanbid ()
Procainamide (hydrochloride) ()
4-amino-N-[2-(diethylamino)ethyl]benzamide ()
Procaine amide (hydrochloride) ()
SP 100 (hydrochloride) ()
Procaine amide ()
SP 100 ()
Procan sr ()
Biocoryl ()
Procainamidi hydrochloridum ()
Novocainamid ()
Procan ()
NSC-757279 ()
Cardiorytmin ()
Amidoprocaine ()
Pronestyl-SR ()
Novocainamide ()
NSC-27461 ()
Sp 100 (pharmaceutical) ()
Procainamida ()
P&D ID
PD009585
CAS
614-39-1
51-06-9
Tags
available
drug
Approved by
FDA
First approval
1950
Drug indication
Atrial fibrillation
Ventricular arrhythmias
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Procainamide hydrochloride (Procaine amide hydrochloride) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide hydrochloride induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide hydrochloride relaxes airway smooth muscle by activating potassium channels. Procainamide hydrochloride can be used in cancer and arrhythmia research[1][2][3][4][5][6].
DESCRIPTION Procainamide is a class Ia antiarrhythmic drug. (GtoPdb)
DESCRIPTION Procainamide (Procaine amide) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide relaxes airway smooth muscle by activating potassium channels. Procainamide can be used in cancer and arrhythmia research[1][2][3][4][5][6].
PRICE 29
DESCRIPTION Procainamide (Novocainamide) is a specific and potent DNA methyltransferase 1 (DNMT1) inhibitor and a Class 1A antiarrhythmic agent, with potential applications in cancer and arrhythmia research [1] [2].
DESCRIPTION Procainamide hydrochloride is an anti-arrhythmic agent and is used to treat cardiac arrhythmia; induces rapid block of the batrachotoxin(BTX)-activated sodium channels of the heart muscle and acts as antagonist to long gating closures. (Enamine Bioactive Compounds)
DESCRIPTION Na+ channel blocker and Class I anti-arrhythmic (LOPAC library)
DESCRIPTION Procainamide Hydrochloride (Procapan) is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential. (TargetMol Bioactive Compound Library)
DESCRIPTION PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) (TargetMol Bioactive Compound Library)
Compound Sets
31
Cayman Chemical Bioactives
24359
ChEMBL Approved Drugs
CHEMBL605
CHEMBL640
ChEMBL Drugs
CHEMBL605
CHEMBL640
Concise Guide to Pharmacology 2017/18
4811
Concise Guide to Pharmacology 2019/20
4811
Concise Guide to Pharmacology 2021/22
4811
Concise Guide to Pharmacology 2023/24
4811
Concise Guide to Pharmacology 2025/26
4811
Drug Repurposing Hub
DrugBank
DB01035
DrugBank Approved Drugs
DB01035
DrugCentral
2270
DrugCentral Approved Drugs
2270
DrugMAP
DMNMXR8
DrugMAP Approved Drugs
DMNMXR8
DrugMatrix
Enamine Bioactive Compounds
EBC-06617
Enamine BioReference Compounds
Guide to Pharmacology
4811
Ki Database
Procainamide
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL640
MedChem Express Bioactive Compound Library
HY-A0084
HY-A0084A
NCATS Inxight Approved Drugs
L39WTC366D
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
procainamide-hcl
TargetMol Bioactive Compound Library
T0018
R090-0020
The Spectrum Collection
External IDs
114
Properties
(calculated by RDKit )
Molecular Weight
235.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
1
Aromatic Ring Count
1
cLogP
1.34
TPSA
58.36
Fraction CSP3
0.46
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
ventricular arrhythmias, ventricular tachycardia (VT)
Target
DNMT1, SCN5A
DNA Methyltransferase,Sodium Channel
DNA Methyltransferase
Potassium Channel
AChR
DNA (cytosine-5)-methyltransferase 1
Sodium Channel
MOA
Sodium Channel blocker
Pathway
Autophagy
Chromatin/Epigenetic
Membrane Transporter/Ion Channel
Neuroscience
Epigenetics
Therapeutic Class
Antiarrhythmic Agents
Source data