General
Preferred name
NOVOBIOCIN
Synonyms
NOVOBIOCIN SODIUM ()
Cathomycin ()
Albamycin ()
Albamycinsodium ()
Novobiocin sodium salt ()
Novobiocin ()
Novobiocin Na+ ()
Novobiocin (Sodium) ()
NOVOBIOCIN CALCIUM ()
Albamycin (sodium) ()
Cathomycin (sodium) ()
Novobiocin Sodium (NSC 2382) ()
Albamycin,Cathomycin,NSC 2382 ()
Novobiocin, monosodium salt ()
Sodium novobiocin ()
Spheromycin ()
Novobiocin monosodium salt ()
NSC-2382 ()
Vulcamycin ()
Albamycin T ()
Novobiocin, calcium salt ()
Calcium novobiocin ()
Novobiocin (sodium salt) ()
P&D ID
PD009577
CAS
1476-53-5
303-81-1
Tags
drug candidate
natural product
drug
available
Approved by
FDA
First approval
1964
Drug Status
investigational
withdrawn
approved
vet_approved
Drug indication
Bacterial infection
Antibacterial
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Novobiocin is an aminocoumarinthat works by inhibiting the GyrB subunit of the bacterial DNA gyrase enzyme involved in energy tranduction. Similar to other aminocoumarin antibiotics, it acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.
DESCRIPTION Novobiocin was originally isolated from the actinomycete Streptomyces niveus and belongs to the aminocoumarins, a class of compounds characterized by a 3-amino-4,7-dihydroxycoumarin ring. It is effective against Gram-positive bacteria but has limited activity against Gram-negative pathogens. (GtoPdb)
Cell lines
2
Organisms
2
Compound Sets
23
Cayman Chemical Bioactives
18457
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL3183453
CHEMBL36506
ChEMBL Drugs
CHEMBL3183453
CHEMBL36506
CHEMBL3544972
Concise Guide to Pharmacology 2023/24
12021
Drug Repurposing Hub
DrugBank
DB01051
DrugBank Approved Drugs
DB01051
DrugCentral
1974
DrugCentral Approved Drugs
1974
DrugMAP
DMRFWGK
DrugMAP Approved Drugs
DMRFWGK
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100340
Guide to Pharmacology
12021
MedChem Express Bioactive Compound Library
HY-B0425A
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Novobiocin-sodium(Albamycin)
TargetMol Bioactive Compound Library
T0974
The Spectrum Collection
Withdrawn 2.0
1000
External IDs
71
Properties
(calculated by RDKit )
Molecular Weight
612.23
Hydrogen Bond Acceptors
11
Hydrogen Bond Donors
5
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
3
cLogP
3.63
TPSA
200.01
Fraction CSP3
0.39
Chiral centers
4.0
Largest ring
6.0
QED
0.18
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
bacterial topoisomerase inhibitor
ABC inhibitor
DNA gyrase inhibitor
Potassium Channel inhibitor
Topoisomerase inhibitor
bacterial DNA gyrase inhibitor
Target
DNA gyrase
ABCG2
Bile salt export pump
Topo I
antibiotic
Bacterial
DNA/RNA Synthesis
HSP
Orthopoxvirus
Antineoplastic and Immunosuppressive Antibiotics,Topoisomerase
Pathway
DNA Damage/DNA Repair
Membrane Transporter/Ion Channel
Anti-infection
Apoptosis
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Indication
mastitis
ATC
J01XX95
Therapeutic Class
Antibiotics
Source data