General
Preferred name
NOVOBIOCIN
Synonyms
NOVOBIOCIN SODIUM ()
U-6391 ()
U 6391 ()
U6391 ()
Cathomycin ()
Albamycin ()
Novobiocin sodium salt ()
Novobiocin ()
Novobiocin Na+ ()
Novobiocin (Sodium) ()
Albamycin (sodium) ()
Cathomycin (sodium) ()
Albamycin,Cathomycin,NSC 2382 ()
Novobiocin Sodium (NSC 2382) ()
NOVOBIOCIN CALCIUM ()
Novobiocin (sodium salt) ()
NSC-2382 ()
Novobiocin, monosodium salt ()
Spheromycin ()
Sodium novobiocin ()
Novobiocin monosodium salt ()
Vulcamycin ()
Novobiocina ()
Albamycin T ()
Novobiocine ()
Novobiocin, calcium salt ()
Calcium novobiocin ()
P&D ID
PD009577
CAS
1476-53-5
303-81-1
Tags
available
drug
natural product
drug candidate
Approved by
FDA
First approval
1964
Drug indication
osteomyelitis
Bacterial infection
Neoplasm
Drug Status
vet_approved
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity[1][2][3][4].
MOA Novobiocin is an aminocoumarinthat works by inhibiting the GyrB subunit of the bacterial DNA gyrase enzyme involved in energy tranduction. Similar to other aminocoumarin antibiotics, it acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.
DESCRIPTION Novobiocin was originally isolated from the actinomycete Streptomyces niveus and belongs to the aminocoumarins, a class of compounds characterized by a 3-amino-4,7-dihydroxycoumarin ring. It is effective against Gram-positive bacteria but has limited activity against Gram-negative pathogens. (GtoPdb)
DESCRIPTION Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus activity[1][2][3][4][6].
PRICE 88
DESCRIPTION Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on gyrase and Hsp90. Novobiocin has anti-positive activity and can be used to study highly resistant pneumococcal infections. (TargetMol Bioactive Compound Library)
Cell lines
4
Organisms
2
Compound Sets
25
Cayman Chemical Bioactives
18457
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL3183453
CHEMBL36506
ChEMBL Drugs
CHEMBL3183453
CHEMBL36506
CHEMBL3544972
Concise Guide to Pharmacology 2023/24
12021
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB01051
DrugBank Approved Drugs
DB01051
DrugCentral
1974
DrugCentral Approved Drugs
1974
DrugMAP
DMRFWGK
DrugMAP Approved Drugs
DMRFWGK
Enamine Bioactive Compounds
EBC-12058
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100340
Guide to Pharmacology
12021
MedChem Express Bioactive Compound Library
HY-B0425A
HY-B0425
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Novobiocin-sodium(Albamycin)
TargetMol Bioactive Compound Library
T20510
The Spectrum Collection
Withdrawn 2.0
1000
External IDs
79
Properties
(calculated by RDKit )
Molecular Weight
612.23
Hydrogen Bond Acceptors
11
Hydrogen Bond Donors
5
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
3
cLogP
3.63
TPSA
200.01
Fraction CSP3
0.39
Chiral centers
4.0
Largest ring
6.0
QED
0.18
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
bacterial topoisomerase inhibitor
ABC inhibitor
DNA gyrase inhibitor
Potassium Channel inhibitor
Topoisomerase inhibitor
bacterial DNA gyrase inhibitor
Target
DNA gyrase
HSP90
antibiotic
Apoptosis
Bacterial
Orthopoxvirus
DNA/RNA Synthesis
HSP
Antineoplastic and Immunosuppressive Antibiotics,Topoisomerase
Indication
mastitis
ATC
J01XX95
Pathway
Cytoskeletal Signaling
DNA Damage/DNA Repair
Metabolism
Microbiology/virology
Anti-infection
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Therapeutic Class
Antibiotics
Source data