General
Preferred name
isoprenaline
Synonyms
ISOPROTERENOL HYDROCHLORIDE ()
(±)-Isoproterenol hydrochloride ()
Medihaler-Iso ()
Isopropylarterenol Sulfate ()
Norisodrine ()
ISOPROTERENOL ()
Isoproterenol (-) ()
Isoproterenol,(+) ()
NCI-c55630 ()
Isoprenaline HCl ()
Isoproterenol sulfate dihydrate ()
ISOPROTERENOL SULFATE ANHYDROUS ()
Isoproterenol HCl ()
ISOPROTERENOL HYDROCHLORIDE51-30-9 ()
Isoprenaline (hydrochloride) ()
Isoproterenol (hydrochloride) ()
NCI-c55630,Isoproterenol hydrochloride ()
Isoprenaline (NCI-C55630) HCl ()
Isoprenaline hydrochloride ()
ISOPROTERENOL SULFATE ()
Norisodrine Aerotrol ()
Dl-isoprenaline hydrochloride ()
Isovon ()
Isoproterenol hydrochloride component of duo-medihaler ()
NSC-89747 ()
Aerotrol ()
Mistarel ()
Vapo-Iso ()
NSC-37745 ()
Oriconazole ()
Euspiran ()
Isoprenaline hydrochloride, dl- ()
Isoproterenol HCl ()
Isomenyl ()
Suscardia ()
Isuprel ()
Isoproterenol dl-form hydrochloride ()
Aerolone ()
Imuprel ()
Asmalar ()
Aludrine ()
Proternol ()
NSC-33791 ()
Isoprenaline ()
NSC-9975 ()
Asiprenol ()
Vapo-n-iso ()
Neodrenal ()
Novodrin ()
Isopropydrin ()
Saventrine ()
A-21 ()
Isonorin ()
Isorenin ()
Isoproterenol dl-form ()
Isoprenalina ()
Isupren ()
Neo-epinine ()
Assiprenol ()
Aleudrin ()
Bellasthman ()
Respifral ()
Isoproterenol dl-form sulfate dihydrate ()
Propal ()
Isoprenalini sulfas ()
Isoprenaline sulfate ()
Isomist ()
Isoprenaline sulfate dihydrate ()
Isoproterenol sulphate ()
Isoprenaline sulphate ()
Aludrin ()
Isoproterenol-d7 (hydrochloride) ()
P&D ID
PD009570
CAS
51-30-9
6779-80-2
114-45-4
1336-89-6
7683-59-2
2964-04-7
149-53-1
6700-39-6
299-95-6
2517584-04-0
Tags
available
drug
biased GPCR ligand
Approved by
FDA
First approval
1956
Drug indication
Congestive heart failure
Melanoma
Atrial fibrillation
Heart block
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active ¦Â-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma[1][2][3][4][5][6].
PRICE 29
DESCRIPTION Isoprenaline is a β-adrenoceptor agonist drug. (GtoPdb)
PRICE 735
DESCRIPTION Isoprenaline(Norisodrine) is a non-selective and orally active ??-adrenoceptor agonist.Isoproterenol is a potent peripheral vasodilator and bronchodilator.Isoproterenol can be used in the study of bradycardia and bronchial asthma for the treatment of heart block, bradycardia.
DESCRIPTION Hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors (Tocris Bioactive Compound Library)
DESCRIPTION Sympathomimetic amine acting almost exclusively on beta adrenoceptors; bronchodilator (LOPAC library)
DESCRIPTION Standard selective β agonist (Tocriscreen Total)
DESCRIPTION Isoprenaline is a non-selective beta adrenergic receptor agonist. It is indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock. (Enamine Bioactive Compounds)
DESCRIPTION Isoprenaline hydrochloride (NCI-c55630) is a potent beta-adrenergic agonist with the peripheral vasodilator, bronchodilator, and cardiac stimulating properties. (TargetMol Bioactive Compound Library)
DESCRIPTION Isoproterenol can be used for the treatment of bradycardia (slow heart rate), heart block, and rarely for asthma. It is a non-selective β adrenoreceptor agonist and TAAR1 agonist that is structurally similar to epinephrine. (BOC Sciences Bioactive Compounds)
Cell lines
2
Organisms
4
Compound Sets
38
AdooQ Bioactive Compound Library
A10484
A17732
BiasDB
Isoprenaline
BOC Sciences Bioactive Compounds
isoproterenol-cas-7683-59-2-item-76832
Cayman Chemical Bioactives
15592
34704
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1711
CHEMBL434
CHEMBL3989521
ChEMBL Drugs
CHEMBL1711
CHEMBL434
CHEMBL3989521
Concise Guide to Pharmacology 2017/18
536
Concise Guide to Pharmacology 2019/20
536
Concise Guide to Pharmacology 2021/22
536
Concise Guide to Pharmacology 2023/24
536
DrugBank
DB01064
DrugBank Approved Drugs
DB01064
DrugCentral
1499
DrugCentral Approved Drugs
1499
DrugMAP
DMK7MEY
DrugMAP Approved Drugs
DMK7MEY
DrugMatrix
Enamine Bioactive Compounds
EBC-12590
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101453
Guide to Pharmacology
536
Ki Database
ISOPRENALINE
Isoproterenol (-)
Isoproterenol,(+)
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1711
CHEMBL434
Mcule NIBR MoA Box Subset
MCULE-6061231962
MedChem Express Bioactive Compound Library
HY-B0468
NCATS Inxight Approved Drugs
052RYF6JDD
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
Isoprenaline-hydrochloride
isoproterenol-sulfate-dihydrate
TargetMol Bioactive Compound Library
T1056
The Spectrum Collection
Tocris Bioactive Compound Library
1747
Tocriscreen Total
External IDs
105
Properties
(calculated by RDKit )
Molecular Weight
211.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
1.13
TPSA
72.72
Fraction CSP3
0.45
Chiral centers
1.0
Largest ring
6.0
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
beta
MOA
Adrenergic Receptor agonist
PDE
Agonist
beta-Adrenoceptor Agonists
Target
Adrenergic receptor beta
Adrenergic Receptor
CAMP PDE
Endogenous Metabolite
PI3K
Primary Target
Non-selective Adrenergic ? Receptors
Member status
member
Pathway
GPCR/G protein
Metabolism
Neuroscience
PI3K/Akt/mTOR signaling
Metabolic Enzyme/Protease
Neuronal Signaling
Therapeutic Class
Cardiotonic Agents
Solubility
Soluble in DMSO
Source data