General
Preferred name
FOSAMPRENAVIR
Synonyms
DIALLYL TRISULFIDE ()
GW433908G ()
FOSAMPRENAVIR CALCIUM ()
Fosamprenavir Calcium Salt ()
Fosamprenavir (Calcium Salt) ()
Amprenavir phosphate ()
GW 433908 ()
GW433908A ()
GW-433908 ()
GW433908 ()
Fosamprenavir calcium salt ()
GW-433908G ()
GW 433908G ()
Lexiva ()
Telzir ()
GW-433908A ()
GW 433908A ()
FOSAMPRENAVIR SODIUM ()
P&D ID
PD009566
CAS
226700-79-4
226700-81-8
226700-80-7
Tags
available
prodrug
drug
drug candidate
Approved by
FDA
First approval
2003
Drug indication
Human immunodeficiency virus infection
HIV infection
HIV-1 infection
Drug Status
investigational
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Fosamprenavir is a prodrug of the HIV-1 protease inhibitor and antiretroviral drug . (GtoPdb)
PHARMACODYNAMICS Fosamprenavir is hydrolyzed by cellular phosphatases to the antiretroviral protease inhibitor amprenavir. This hydrolysis allows for the slow release of amprenavir, reducing the number of pills a patient must take.
DESCRIPTION Fosamprenavir (Amprenavir phosphate;GW 433908) is a phosphate ester proagent of the antiretroviral protease inhibitor Amprenavir, with improved solubility[1]. Anti-HIV infection[1].
DESCRIPTION Fosamprenavir Calcium Salt (GW433908G) is a phosphate ester proagent of the antiretroviral protease inhibitor Amprenavir, with improved solubility[1]. Anti-HIV infection[1].
PRICE 250
DESCRIPTION HIV protease inhibitor; water soluble prodrug of amprenavir. (BOC Sciences Bioactive Compounds)
DESCRIPTION Fosamprenavir Calcium Salt (GW433908G) (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility. Fosamprenavir Calcium Salt has Anti-HIV infection. (TargetMol Bioactive Compound Library)
Compound Sets
18
AdooQ Bioactive Compound Library
A12583
BOC Sciences Bioactive Compounds
fosamprenavir-calcium-salt-cas-226700-81-8-item-84-63371
ChEMBL Approved Drugs
CHEMBL1664
CHEMBL1200734
ChEMBL Drugs
CHEMBL1664
CHEMBL1200734
CHEMBL2106751
Drug Repurposing Hub
DrugBank
DB01319
DrugBank Approved Drugs
DB01319
DrugCentral
1240
DrugCentral Approved Drugs
1240
DrugMAP
DM4W9B3
DrugMAP Approved Drugs
DM4W9B3
Guide to Pharmacology
12682
MedChem Express Bioactive Compound Library
HY-78726
HY-17431
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
fosamprenavir-calcium-salt
TargetMol Bioactive Compound Library
T8238
External IDs
120
Properties
(calculated by RDKit )
Molecular Weight
585.19
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
4
Rotatable Bonds
13
Ring Count
3
Aromatic Ring Count
2
cLogP
2.52
TPSA
177.72
Fraction CSP3
0.48
Chiral centers
3.0
Largest ring
6.0
QED
0.2
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
HIV
HIV Protease
Drug intermediate
Endogenous Metabolite
Indication
human immunodeficiency virus (HIV-1)
MOA
HIV Protease inhibitor
Therapeutic Class
Anti-HIV Agents
Pathway
Anti-infection
Metabolic Enzyme/Protease
Microbiology/virology
Proteases/Proteasome
Solubility
In Vitro:<br/>DMSO : 50 mg/mL(80.17 mM
Need ultrasonic)<br/>H2O : 0.25 mg/mL(0.40 mM
Need ultrasonic and warming)<br/>In Vivo:<br/>1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline<br/>Solubility: ≥ 2.5 mg/mL (4.01 mM)
Clear solution<br/>2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline)<br/>Solubility: ≥ 2.5 mg/mL (4.01 mM)
Clear solution<br/>3.Add each solvent one by one:10% DMSO >> 90%corn oil<br/>Solubility: ≥ 2.5 mg/mL (4.01 mM)
Clear solution
Source data