General
Preferred name
FOSPHENYTOIN
Synonyms
FOSPHENYTOIN SODIUM ()
ACC-9653 ()
Fosphenytoin (disodium) ()
Fosphenytoin disodium ()
Fosphenytoin (sodium salt) ()
Fosfenitoina ()
Fosphenytoine ()
Np-06 ()
ACC-9653-010 (SODIUM SALT) ()
Sesquient ()
Fosphenytoin disodium salt ()
Pro-Epanutin ()
Cerebyx ()
CI-982 ()
CI 982 ()
P&D ID
PD009565
CAS
93390-81-9
92134-98-0
Tags
available
prodrug
drug
Approved by
FDA
First approval
1996
Drug indication
Epilepsy
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Fosphenytoin is a prodrug of phenytoin. This drug is an anticonvulsant.
Marketed formulations may contain fosphenytoin sodium (PubChem CID 56338). (GtoPdb)
Marketed formulations may contain fosphenytoin sodium (PubChem CID 56338). (GtoPdb)
PRICE
46
PRICE
29
DESCRIPTION
Fosphenytoin is a phosphate prodrug that can be used as an alternative to intravenous phenytoin for the acute intervention of seizures.Fosphenytoin is hydrolyzed to anticonvulsant phenytoin when administered parenterally.Fosphenytoin can be used in a variety of delivery modes such as intravenous and intraperitoneal.Fosphenytoin can be used in a variety of delivery modes such as intravenous and intraperitoneal.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Fosphenytoin disodium (ACC-9653) is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
64
Molecular Weight
362.07
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
1.55
TPSA
116.17
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Sodium Channel
SCN5A
Indication
epilepsy, seizures
MOA
Sodium Channel blocker
Therapeutic Class
Anticonvulsants
Pathway
Membrane Transporter/Ion Channel
Source data
