General
Preferred name
CEFAMANDOLE
Synonyms
Cefamandole sodium salt ()
Cefamandole (sodium) ()
CEFAMANDOLE SODIUM ()
Cephamandole sodium ()
NSC-758169 ()
Compound 83405 ()
J01DC03 ()
COMPOUND-83405 ()
Cephamandole ()
Cefamandole (sodium salt) ()
P&D ID
PD009562
CAS
30034-03-8
34444-01-4
Tags
covalent binder
drug candidate
natural product
drug
available
Drug Status
experimental
approved
Drug indication
Antibacterial
Microorganisms infection
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
The parenteral prodrug formate ester cefamandole nafate is a broad-spectrum cephalosporin antibiotic. The bactericidal action of cefamandole results from inhibition of cell-wall synthesis. Cephalosporins have in vitro activity against a wide range of gram-positive and gram-negative organisms.
DESCRIPTION
Cefamandole is a semisynthetic, second generation cephalosporin belonging to the β-lactam class of antibacterial compounds . It has broad-spectrum activity and is β-lactamase-resistant. It is administered parenterally as the prodrug cefamandole nafate.
Because of its inhibitory activity towards human aldehyde dehydrogenase, cefamandole produces an effect to ethanol similar to that produced by (Antabuse®). (GtoPdb)
Because of its inhibitory activity towards human aldehyde dehydrogenase, cefamandole produces an effect to ethanol similar to that produced by (Antabuse®). (GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CovBinderInPDB
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Other bioactive compounds
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
57
Molecular Weight
462.08
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
2
cLogP
-0.23
TPSA
150.54
Fraction CSP3
0.33
Chiral centers
3.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Bacterial
antibiotic
Pathway
Anti-infection
Indication
skin infections, urinary tract infections, respiratory tract infections
MOA
bacterial cell wall synthesis inhibitor
Therapeutic Class
Antibiotics
Source data
