General
Preferred name
CEFAZOLIN
Synonyms
CEFAZOLIN SODIUM ()
Ancef ()
Cefazolin sodium salt ()
Sodium cephazolin ()
cephazolin sodium ()
cefazoline sodium ()
Sodium cefazolin ()
Cefazolin (sodium) ()
Cephazolin (sodium) ()
Cephazolin ()
cefazoline sodium, cephazolin sodium, Ancef ()
Cefazolin (sodium salt) ()
Cefazolin-13C2,15N ()
Cefazil ()
Cefamedin ()
Cefazolin injection ()
SK&F 41558 ()
Totacef ()
SK&F-41558 ()
Cefazolin and dextrose ()
Gramaxin ()
Cefamezin ()
Kefzol ()
Zolicef ()
Acef ()
46083 ()
NSC-291561 ()
Cefacidal ()
Cefazoline ()
Cefazolina ()
J01DB04 ()
P&D ID
PD009561
CAS
27164-46-1
25953-19-9
115850-11-8
2101505-58-0
Tags
available
drug
Approved by
FDA
First approval
1973
Drug indication
infection
Endocarditis
Bacterial infection
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cefazolin sodium is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research[1]. Cefazolin sodium has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD)[2].
PRICE 29
DESCRIPTION Cefazolin is a β-lactam and first-generation cephalosporin antibacterial. (GtoPdb)
PRICE 29
DESCRIPTION Cefazolin (Cephazolin) is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research[1]. Cefazolin has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD)[2].
DESCRIPTION Semi-synthetic antibiotic; interferes with cell wall synthesis (LOPAC library)
DESCRIPTION Cefazolin sodium is a broad-spectrum first-generation cephalosporin antibiotic. (Enamine Bioactive Compounds)
DESCRIPTION Cefazolin sodium (cephazolin sodium) salt binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Cefazolin sodium salt is the sodium salt of cefazolin, a beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, which results in the weakening of the bacterial cell wall and cell lysis. (TargetMol Bioactive Compound Library)
DESCRIPTION Cefazolin is a semi-synthetic cephalosporin that has a broad spectrum of antibacterial activity and inhibits the synthesis of bacterial cell walls. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
25
Cayman Chemical Bioactives
15776
25319
ChEMBL Approved Drugs
CHEMBL1200523
CHEMBL1435
ChEMBL Drugs
CHEMBL1200523
CHEMBL1435
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB01327
DrugBank Approved Drugs
DB01327
DrugCentral
530
DrugCentral Approved Drugs
530
DrugMAP
DMPDYFR
DrugMAP Approved Drugs
DMPDYFR
Enamine Bioactive Compounds
EBC-08481
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100569
Guide to Pharmacology
10935
LOPAC library
MedChem Express Bioactive Compound Library
HY-B1078
HY-B1892
NCATS Inxight Approved Drugs
IHS69L0Y4T
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
cefazolin-sodium
cefazolin
TargetMol Bioactive Compound Library
T0953
T8390
The Spectrum Collection
External IDs
81
Properties
(calculated by RDKit )
Molecular Weight
454.03
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
2
cLogP
-0.64
TPSA
156.09
Fraction CSP3
0.43
Chiral centers
2.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Cell wall synthesis
Target
antibiotic
Bacterial
PBPs
Peptidoglycan synthase
PON
PON1
Antibiotics,Bacterial
Member status
member
MOA
paraoxonase 1 inhibitor
Antibiotic
bacterial cell wall synthesis inhibitor
Indication
urinary tract infections, skin infections, bacterial septicemia, endocarditis, surgical prophylaxis, bone and joint infections
Pathway
Microbiology/virology
Anti-infection
Therapeutic Class
Antibiotics
Source data