General
Preferred name
CEFTIZOXIME
Synonyms
Epocelin ()
CEFTIZOXIME SODIUM ()
Ceftizoxime (sodium) ()
SKF-88373 ()
FK-749 ()
FR 13749 ()
SK&F 88373-Z ()
Cefizox ()
FK 749 ()
FR-13749 ()
Sodium ceftizoxime ()
Ceftizoxime sodium salt ()
SK&F-88373-Z ()
Ceftizoxime (sodium salt) ()
P&D ID
PD009556
CAS
68401-81-0
68401-82-1
Tags
natural product
drug
available
Approved by
FDA
First approval
1983
Drug Status
approved
withdrawn
Drug indication
Bacterial infection
Antibacterial
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ceftizoxime is a semisynthetic, broad-spectrum, β-lactamase-resistant, parenterally administered third-generation cephalosporin antibacterial with Gram +ve and Gram -ve activity. Unlike other third-generation cephalosporins, ceftizoxime's C-3 side chain has been removed to prevent deactivation by hydrolytic enzymes. (GtoPdb)
Compound Sets
18
Cayman Chemical Bioactives
36093
ChEMBL Approved Drugs
CHEMBL1201019
CHEMBL528
ChEMBL Drugs
CHEMBL1201019
CHEMBL528
Drug Repurposing Hub
DrugBank
DB01332
DrugBank Approved Drugs
DB01332
DrugCentral
563
DrugCentral Approved Drugs
563
DrugMAP
DM3VOGS
DrugMAP Approved Drugs
DM3VOGS
Guide to Pharmacology
10785
MedChem Express Bioactive Compound Library
HY-B1596A
HY-B1596
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
ceftizoxime-sodium
ceftizoxime
TargetMol Bioactive Compound Library
T4501
Withdrawn 2.0
1032
External IDs
60
Properties
(calculated by RDKit )
Molecular Weight
383.04
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
1
cLogP
-0.56
TPSA
147.21
Fraction CSP3
0.31
Chiral centers
2.0
Largest ring
6.0
QED
0.35
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Anti-infection
Target
Antibacterial
antibiotic
Bacterial
Penicillin-binding protein (PBP)
Indication
respiratory tract infections, urinary tract infections, gonorrhea, pelvic inflammatory disease, intra-abdominal infections, bacterial septicemia, skin infections, bone and joint infections, meningitis
MOA
bacterial cell wall synthesis inhibitor
ATC
J01DD07
Therapeutic Class
Antibiotics
Source data