General
Preferred name
CEFTIZOXIME
Synonyms
Epocelin ()
Ceftizoxime (sodium) ()
CEFTIZOXIME SODIUM ()
SKF-88373 ()
SK&F-88373-Z ()
Sodium ceftizoxime ()
FR 13749 ()
Cefizox ()
FK 749 ()
Ceftizoxime sodium salt ()
SK&F 88373-Z ()
FR-13749 ()
FK-749 ()
Ceftizoxima ()
Ceftizoxime (sodium salt) ()
P&D ID
PD009556
CAS
68401-82-1
68401-81-0
Tags
available
drug
Approved by
FDA
First approval
1983
Drug indication
osteomyelitis
Bacterial infection
Drug Status
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ceftizoxime is a semisynthetic, broad-spectrum, β-lactamase-resistant, parenterally administered third-generation cephalosporin antibacterial with Gram +ve and Gram -ve activity. Unlike other third-generation cephalosporins, ceftizoxime's C-3 side chain has been removed to prevent deactivation by hydrolytic enzymes.
(GtoPdb)
PRICE
29
DESCRIPTION
Ceftizoxime is a bacterial inhibitor which acts by interfering with bacterial cell wall synthesis and inhibiting cross-linking of the peptidoglycan.
DESCRIPTION
Ceftizoxime (Epocelin) is a cephalosporin-based, potent antibacterial agent which can be administered intravenously or by suppository. It is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
63
Molecular Weight
383.04
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
1
cLogP
-0.56
TPSA
147.21
Fraction CSP3
0.31
Chiral centers
2.0
Largest ring
6.0
QED
0.35
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Antibacterial
antibiotic
Bacterial
Penicillin-binding protein (PBP)
Indication
respiratory tract infections, urinary tract infections, gonorrhea, pelvic inflammatory disease, intra-abdominal infections, bacterial septicemia, skin infections, bone and joint infections, meningitis
MOA
bacterial cell wall synthesis inhibitor
ATC
J01DD07
Pathway
Microbiology/virology
Anti-infection
Therapeutic Class
Antibiotics
Source data
