General
Preferred name
Cefradine
Synonyms
Sefril ()
Cephradine ()
cephradine ()
Cephradine (monohydrate) ()
Cefradine (monohydrate) ()
SQ-11436 ()
Cephradine, Sefril, Anspor, Cephradin, Velosef ()
Cephradine monohydrate ()
Ecosporina ()
Cephradine anhydrous ()
Cefradine hydrate ()
Velosef '250' ()
SQ 22022 [DIHYDRATE] ()
Nicef ()
Velosef ()
Cephradine, unspecified hydrate ()
SQ-22022 ()
Anspor ()
NSC-756672 ()
SK&F D-39304 ()
Cefradina ()
Velosef '125' ()
SK&F-D-39304 ()
SK-D-39304 ()
Cephradine hydrate ()
SQ 11436 ()
Velosef '500' ()
Cefradin ()
P&D ID
PD009555
CAS
38821-53-3
75975-70-1
Tags
available
drug
Approved by
FDA
First approval
1974
Drug indication
bacterial disease
Bacterial infection
Drug Status
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cefradine is a cephalosporin antibacterial.
(GtoPdb)
DESCRIPTION
Cephradine (Cefradine) is a broad-spectrum and orally active cephalosporin. Cephradine is active against both gram-positive and gram-negative pathogens. Cephradine is effective in eradicating most penicillinase-producing organisms. Cephradine has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK[1][2][3].
DESCRIPTION
Cephradine (Cefradine) monohydrate is a broad-spectrum and orally active cephalosporin. Cephradine monohydrate is active against both grampositive and gram-negative pathogens and effective in eradicating most penicillinase-producing organisms known to be resistant to penicillin G, penicillin V, and ampicillin. Cephradine monohydrate has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine monohydrate blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK[1][2][3].
DESCRIPTION
Cefradine is a first-generation cephalosporin antibiotic used in the treatment of bacterial infections of the respiratory and urinary tracts and of the skin and soft tissues.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
22
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
48
Molecular Weight
349.11
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
0
cLogP
0.35
TPSA
112.73
Fraction CSP3
0.44
Chiral centers
3.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Disease Area
infectious disease, otolaryngology
Indication
respiratory tract infections, otitis, skin infections, urinary tract infections, tonsillitis, pharyngitis, pneumonia
Target
CYP3A4
antibiotic
Bacterial
TOPK
Antibiotics,Bacterial
MOA
bacterial cell wall synthesis inhibitor
ATC
J01DB09
Therapeutic Class
Antibiotics
Pathway
Anti-infection
Cell Cycle/DNA Damage
Source data
