General
Preferred name
HEXOBARBITAL
Synonyms
HEXOBARBITAL SODIUM ()
Evipal ()
Hexobarbital ciii ()
Sombucaps ()
Enhexymal ()
NSC-71929 ()
Sombulex ()
Evipal sodium ()
NSC-255103 ()
Hexobarbital sodium salt ()
P&D ID
PD009536
CAS
7200-11-5
56-29-1
Tags
drug candidate
natural product
drug
available
First approval
1932
Drug indication
Anaesthesia
Drug Status
experimental
approved
withdrawn
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
Hexobarbital is a barbiturate derivative having hypnotic and sedative effects. It was subsequently used in the 1940s and 1950s as an anesthetic for surgery. Furthermore, the agent also demonstrates a fairly quick onset of action that also possesses a short duration of action. However it can be difficult to control the depth of anesthesia with hexobarbital which makes it quite dangerous, and it has now been replaced by safer drugs in human medicine, usually thiopental would be the barbiturate of choice for this application these days.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
ChEMBL Drugs
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
NPC Screening Collection
ReFrame library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
236.12
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
0
cLogP
1.2
TPSA
66.48
Fraction CSP3
0.58
Chiral centers
1.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
ATC
N05CA16
N01AF02
Toxicity type
respiratory
Therapeutic Class
Hypnotics and Sedatives
Source data
