General
Preferred name
penbutolol
Synonyms
PENBUTOLOL SULFATE ()
Penbutolol (sulfate) ()
(-)-Terbuclomine ()
Levatol ()
HOE-893D ()
NSC-760043 ()
HOE-39-893D ()
HOE 39-893D ()
HOE 893D ()
Penbutolol sulphate ()
Betapressin ()
Penbutolol (hemisulfate) ()
P&D ID
PD009534
CAS
38363-40-5
36507-48-9
38363-32-5
Tags
natural product
drug
available
Approved by
FDA
First approval
1987
Drug Status
investigational
approved
Drug indication
Hypertension
Anti-Adrenergic (beta-receptor)
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
HALF-LIFE Plasma= approximately 5h; Conjugated= approximately 20h in healthy persons, 25h in healthy elderly persons, and 100h in patients on renal dialysis.
DESCRIPTION Penbutolol is a β-adrenoceptor antagonist (β-blocker). (GtoPdb)
Compound Sets
15
Cayman Chemical Bioactives
29524
ChEMBL Approved Drugs
CHEMBL1290
CHEMBL2361370
ChEMBL Drugs
CHEMBL1290
CHEMBL2361370
Drug Repurposing Hub
DrugBank
DB01359
DrugBank Approved Drugs
DB01359
DrugCentral
2078
DrugCentral Approved Drugs
2078
DrugMAP
DM4ES8F
DrugMAP Approved Drugs
DM4ES8F
Guide to Pharmacology
7263
MedChem Express Bioactive Compound Library
HY-B1154
NPC Screening Collection
Selleckchem Bioactive Compound Library
penbutolol-sulfate
The Spectrum Collection
External IDs
54
Properties
(calculated by RDKit )
Molecular Weight
291.22
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
1
cLogP
3.47
TPSA
41.49
Fraction CSP3
0.67
Chiral centers
1.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ADRB1, ADRB2, HTR1A, HTR1B
Adrenergic Receptor
Indication
hypertension
MOA
Adrenergic Receptor antagonist
Therapeutic Class
Antihypertensive Agents
Pathway
GPCR/G protein
Neuronal Signaling
Source data