General
Preferred name
penbutolol
Synonyms
PENBUTOLOL SULFATE ()
(-)-Terbuclomine ()
Penbutolol (sulfate) ()
(s)-penbutolol ()
(-)-isopenbutolol ()
(-)-penbutolol ()
Levatol ()
NSC-760043 ()
HOE-893D ()
HOE 893D ()
Betapressin ()
HOE 39-893D ()
HOE-39-893D ()
Penbutolol sulphate ()
Penbutolol (hemisulfate) ()
P&D ID
PD009534
CAS
38363-40-5
36507-48-9
38363-32-5
Tags
available
drug
Approved by
FDA
First approval
1987
Drug indication
Hypertension
Cardiovascular disease
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
HALF-LIFE
Plasma= approximately 5h; Conjugated= approximately 20h in healthy persons, 25h in healthy elderly persons, and 100h in patients on renal dialysis.
DESCRIPTION
Penbutolol is a β-adrenoceptor antagonist (β-blocker).
(GtoPdb)
PRICE
29
DESCRIPTION
Penbutolol sulfate ((-)-Terbuclomine) binds to both ??2-adrenergic and ??1-adrenergic receptors, making it a non-selective ??-blocker.
DESCRIPTION
Penbutolol sulfate ((-)-Terbuclomine) binds to both β2-adrenergic and β1-adrenergic receptors, making it a non-selective β-blocker.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
58
Molecular Weight
291.22
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
1
cLogP
3.47
TPSA
41.49
Fraction CSP3
0.67
Chiral centers
1.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Adrenergic Receptor
β1-adrenergic receptor
β2-adrenergic receptor
ADRB1, ADRB2, HTR1A, HTR1B
5-HT Receptor
Indication
hypertension
MOA
Adrenergic Receptor antagonist
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Therapeutic Class
Antihypertensive Agents
Source data
