General
Preferred name
TROLEANDOMYCIN
Synonyms
Troleandomycin ()
troleandomycin, Elan ()
Triacetyloleandomycin ()
Oleandomycin (as troleandomycin) ()
Troleandomycine ()
Troleandomicina ()
Oleandomycin triacetate ester ()
Acetyloleandomycin ()
NSC-108166 ()
P&D ID
PD009533
CAS
2751-09-9
Tags
available
drug
Approved by
FDA
First approval
1969
Drug indication
osteomyelitis
Bacterial infection
Drug Status
withdrawn
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Troleandomycin (Triacetyloleandomycin), a macrolide acrolide antibiotic, is a selective CYP3A inhibitor. Troleandomycin is an oral corticosteroid for asthma study[1][2][3].
PRICE 22
DESCRIPTION Troleandomycin (Triacetyloleandomycin), a macrolide antibiotic, is an orally active and specific CYP3A inhibitor that induces mnemonic speech, induces prolonged cholestasis, and can be used in the study of asthma.
Compound Sets
13
ChEMBL Approved Drugs
CHEMBL564085
ChEMBL Drugs
CHEMBL564085
Drug Repurposing Hub
DrugBank
DB13179
DrugBank Approved Drugs
DB13179
DrugCentral
2769
DrugCentral Approved Drugs
2769
DrugMAP
DMUZNIG
DrugMAP Approved Drugs
DMUZNIG
MedChem Express Bioactive Compound Library
HY-108881
Prestwick Chemical Library
ReFrame library
Withdrawn 2.0
999
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
813.45
Hydrogen Bond Acceptors
16
Hydrogen Bond Donors
0
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
0
cLogP
3.62
TPSA
184.19
Fraction CSP3
0.88
Chiral centers
18.0
Largest ring
14.0
QED
0.19
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Disease Area
infectious disease, pulmonary, otolaryngology
Indication
pneumonia, bronchitis, tonsillitis, sinusitis
MOA
protein synthesis inhibitor
ATC
J01FA08
Pathway
Anti-infection
Metabolic Enzyme/Protease
Therapeutic Class
Antibiotics
Target
antibiotic
Bacterial
Cytochrome P450
Source data