General
Preferred name
drospirenone
Synonyms
ZK 3059 ()
Dihydrospirorenone ()
Slinda ()
Drospirenone component of beyaz ()
Drospirenone component of nextstellis ()
ZK 30595 ()
Drospirenona ()
Drospirenone component of angeliq ()
Drospirenone component of yasmin ()
ZK-30595 ()
Drospirenone component of yaz ()
Slynd ()
Drospirenone component of safyral ()
NSC-760103 ()
Drospirenone-13C3 ()
P&D ID
PD009518
CAS
67392-87-4
Tags
available
drug
Approved by
FDA
PMDA
EMA
First approval
2010
2001
Drug indication
polycystic ovary syndrome
Contraception
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Drospirenone is a synthetic analog of spironolactone. As a contraceptive agent it is used for its progestin-like activity, but it also has anti-androgen and anti-mineralocorticoid properties.
DESCPRITION a progestational compound with antimineralocorticoid and antiandrogenic activity; structure given in first source
DESCRIPTION Drospirenone is a synthetic analogue of , that has a similar pharmacological profile to endogenous . As a contraceptive agent it is used for its progestin-like activity, but it also has anti-androgen and anti-mineralocorticoid properties. (GtoPdb)
DESCRIPTION Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. [1][2][3][4].
PRICE 35
DESCRIPTION Drospirenone (ZK 3059) is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity. (TargetMol Bioactive Compound Library)
Compound Sets
21
AdooQ Bioactive Compound Library
A10336
Cayman Chemical Bioactives
23347
34008
ChEMBL Approved Drugs
CHEMBL1509
ChEMBL Drugs
CHEMBL1509
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB01395
DrugBank Approved Drugs
DB01395
DrugCentral
968
DrugCentral Approved Drugs
968
DrugMAP
DM1A9W3
DrugMAP Approved Drugs
DM1A9W3
EU-OPENSCREEN Bioactive Compound Library
EOS101705
Guide to Pharmacology
2874
MedChem Express Bioactive Compound Library
HY-B0111
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
N295J34A25
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
Drospirenone
TargetMol Bioactive Compound Library
T1541
External IDs
46
Properties
(calculated by RDKit )
Molecular Weight
366.22
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
7
Aromatic Ring Count
0
cLogP
4.31
TPSA
43.37
Fraction CSP3
0.83
Chiral centers
10.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Androgen Receptor
COX-2
Mineralocorticoid Receptor
PR
Progesterone Receptor
AR, NR3C2, PGR
Estrogen/progestogen Receptor
Indication
contraceptive
MOA
Mineralocorticoid Receptor Antagonist
Biosynthetic Origin
Terpenoid (Steroid)
Therapeutic Indication
Contraception
Therapeutic Class
Hormone Therapy
Contraceptive Agents
Pathway
Endocrinology/Hormones
Immunology/Inflammation
Neuroscience
Vitamin D Related/Nuclear Receptor
Source data