General
Preferred name
drospirenone
Synonyms
Dihydrospirorenone ()
ZK 3059 ()
Slinda ()
Angeliq ()
Slynd ()
NSC-760103 ()
ZK 30595 ()
ZK-30595 ()
Drospirenone-13C3 ()
P&D ID
PD009518
CAS
67392-87-4
Tags
natural product
drug
available
Approved by
PMDA
EMA
FDA
First approval
2001
2010
Drug Status
approved
Drug indication
Aldosterone Antagonist
Contraception
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Drospirenone is a synthetic analogue of , that has a similar pharmacological profile to endogenous . As a contraceptive agent it is used for its progestin-like activity, but it also has anti-androgen and anti-mineralocorticoid properties.
(GtoPdb)
DESCPRITION
a progestational compound with antimineralocorticoid and antiandrogenic activity; structure given in first source
DESCRIPTION
Drospirenone is a synthetic analog of spironolactone. As a contraceptive agent it is used for its progestin-like activity, but it also has anti-androgen and anti-mineralocorticoid properties.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
20
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Properties
(calculated by RDKit )
Molecular Weight
366.22
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
7
Aromatic Ring Count
0
cLogP
4.31
TPSA
43.37
Fraction CSP3
0.83
Chiral centers
10.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Immunology/Inflammation
Endocrinology/Hormones
Neuroscience
Vitamin D Related/Nuclear Receptor
Target
Androgen Receptor
COX-2
PR
Mineralocorticoid Receptor
AR, NR3C2, PGR
Progesterone Receptor
Estrogen/progestogen Receptor
Indication
contraceptive
MOA
Mineralocorticoid Receptor Antagonist
Biosynthetic Origin
Terpenoid (Steroid)
Therapeutic Indication
Contraception
Therapeutic Class
Hormone Therapy
Contraceptive Agents
Source data