General
Preferred name
DIGITOXIN
Synonyms
Digitoxoside ()
Unidigin ()
Digitoxinum ()
Glucodigin ()
Tradigal ()
Digitophyllin ()
NSC-7529 ()
Nativelle Digitaline ()
Purpurid ()
Cristapurat ()
Lanatoxin ()
Crystodigin ()
Digitalin, crystalline ()
Digimerck ()
P&D ID
PD009517
CAS
71-63-6
Tags
natural product
drug
available
Approved by
FDA
Drug Status
investigational
approved
withdrawn
Drug indication
Heart failure
Cardiotonic
Congestive cardiac insufficiency
Arrhythmia
Max Phase
Phase 4
First approval
1982
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Digitoxin is a cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting (From Martindale, The Extra Pharmacopoeia, 30th ed, p665). It is eliminated hepatically making it useful in patients with poor or erratic kidney function, although it is now rarely used in practice. Digitoxin lacks the strength of evidence that digoxin has in the management of heart failure.
TOXICITY Digitoxin exerts similar toxic effects to digoxin including anorexia, nausea, vomiting, diarrhoea, confusion, visual disturbances, and cardiac arrhythmias.
DESCRIPTION Sodium/potassium-transporting ATPase inhibitor (pan) (GtoPdb)
Cell lines
19
Organisms
1
Compound Sets
20
Cayman Chemical Bioactives
27825
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL254219
ChEMBL Drugs
CHEMBL254219
Drug Repurposing Hub
DrugBank
DB01396
DrugBank Approved Drugs
DB01396
DrugCentral
881
DrugCentral Approved Drugs
881
DrugMAP
DMWVIGP
DrugMAP Approved Drugs
DMWVIGP
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101960
Guide to Pharmacology
6782
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL254219
MedChem Express Bioactive Compound Library
HY-B1357
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
T0295
Withdrawn 2.0
1083
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
764.43
Hydrogen Bond Acceptors
13
Hydrogen Bond Donors
5
Rotatable Bonds
7
Ring Count
8
Aromatic Ring Count
0
cLogP
3.25
TPSA
182.83
Fraction CSP3
0.93
Chiral centers
20.0
Largest ring
6.0
QED
0.19
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
sodium-potassium transporting ATPase inhibitor
ATPase inhibitor
Target
Sodium/potassium-transporting ATPase
organic anion transporter
Na+/K+-ATPase
ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, FXYD2
Bcl-2 Family
Calcium Channel
Caspase
HSV
Na+/K+ ATPase
Pathway
Membrane Transporter/Ion Channel
Anti-infection
Apoptosis
Neuronal Signaling
Indication
congestive heart failure, cardiac arrythmia
ATC
C01AA04
Therapeutic Class
Antiarrhythmic Agents
Source data