General
Preferred name
NEOSTIGMINE
Synonyms
NEOSTIGMINE BROMIDE ()
NEOSTIGMINE METHYLSULFATE ()
CHEMBL54126 ()
Neoserine bromide ()
Eustigmin bromide ()
Neostigmine methyl sulfate ()
Normastigmin ()
Syntostigmin ()
Hodostin ()
Neostigmine (Bromide) ()
Neostigmine (methyl sulfate) ()
neostigmine methylsulfate, Flamel Technologies ()
Neostigmine methyl sulfate, Syntostigmin, Neostigmeth ()
Neostigmine Iodide ()
Syntostigmin bromide ()
Neoproserine ()
Neo proserine ()
NSC-757233 ()
Neostigmini bromidum ()
Vagostigmin ()
Neostigmine ()
Kirkstigmine bromide ()
Robinul-Neostig ()
NSC-93753 ()
Neostigmini metilsulfas ()
Neostigmine metilsulfate ()
Bloxiverz ()
Prostigmine ()
Intrastigmina ()
Neostigmine methylsulphate ()
Neostigmine (cation) ()
Neostigmine hydroxide ()
Neostigmine cation ()
Neostigmine ion ()
Miostin ()
P&D ID
PD009515
CAS
51-60-5
114-80-7
59-99-4
1212-37-9
Tags
available
probe
drug
Approved by
FDA
First approval
2013
Drug Status
approved
vet_approved
Drug indication
Myasthenia gravis
Cholinergic
Max Phase
Phase 4
Probe info
Probe type
calculated probe
Probe sources
Tool Compound Set
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. By inhibiting acetylcholinesterase, more acetylcholine is available in the synapse, therefore, more of it can bind to the fewer receptors present in myasthenia gravis and can better trigger muscular contraction.; ;
DESCRIPTION Neostigmine is a peripherally acting, reversible acetylcholinesterase (ACHE) inhibitor. Marketed formulations contain neostigmine bromide (PubChem CID 8246) or neostigmine methylsulfate (CID 5824). (GtoPdb)
DESCRIPTION Neostigmine bromide(Prostigmin) is a reversible acetylcholinesterase inhibitor and a parasympatho-mimetic. (BOC Sciences Bioactive Compounds)
DESCRIPTION This active molecular is a reversible acetylcholinesterase inhibitor as a parasympathomimetic compound under the development of Flamel Technologies. Neostigmine Iodide is used to improve muscle tone in people with myasthenia gravis and it can also be used to reverse the effects of non-depolarizing muscle relaxants at the end of the surgery. Neostigmine Iodide also can be applicated for urinary retention resulting from general anesthesia and to treat curariform drug toxicity. (BOC Sciences Bioactive Compounds)
DESCRIPTION Reversible inhibitor of acetylcholinesterase (LOPAC library)
Cell lines
0
Organisms
3
Compound Sets
28
AdooQ Bioactive Compound Library
A10635
BOC Sciences Bioactive Compounds
neostigmine-bromide-cas-114-80-7-item-84-290531
neostigmine-iodide-cas-1212-37-9-item-475153
Cayman Chemical Bioactives
23501
ChEMBL Approved Drugs
CHEMBL211471
CHEMBL54126
CHEMBL278020
ChEMBL Drugs
CHEMBL211471
CHEMBL54126
CHEMBL278020
Drug Repurposing Hub
DrugBank
DB01400
DrugBank Approved Drugs
DB01400
DrugCentral
1897
DrugCentral Approved Drugs
1897
DrugMAP
DM6T2J3
DrugMAP Approved Drugs
DM6T2J3
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101353
Guide to Pharmacology
8993
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL211471
CHEMBL54126
CHEMBL278020
MedChem Express Bioactive Compound Library
HY-B1206
HY-B0423
NCATS Inxight Approved Drugs
3982TWQ96G
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
hodostin
Neostigmine-bromide(Prostigmin)
TargetMol Bioactive Compound Library
T1612
T1624
The Spectrum Collection
Tool Compound Set
External IDs
84
Properties
(calculated by RDKit )
Molecular Weight
223.14
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
1.94
TPSA
29.54
Fraction CSP3
0.42
Chiral centers
0.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Acetylcholinesterase
Pathway
Neuroscience
Neuronal Signaling
Target
AChE
AChR
Cholinesterase (ChE)
MOA
AChR inhibitor
Acetylcholinesterase Inhibitors
Acetylcholinesterase inhibitor
Member status
member
Indication
myasthenia gravis
Therapeutic Class
Parasympathomimetics
Solubility
Soluble in DMSO
Source data