General
Preferred name
methotrimeprazine
Synonyms
levomepromazine ()
Methotrimeprazine maleat salt ()
LEVOMEPROMAZINE MALEATE ()
LEVOMEPROMAZINE HYDROCHLORIDE ()
Nozinan ()
Neuractil ()
Neurocil ()
Sofmin ()
Tisercin ()
Levomepromazinum ()
Minozinan ()
Levinan ()
Veractil ()
Hirnamin ()
Levomepromazine hydrogen maleate ()
Milezin ()
CL 36467 ()
XP03 ()
Nirvan ()
SK&F-5116 ()
CL 39743 ()
RP-7044 ()
RP 7044 ()
CL-36467 ()
CL-39743 ()
N05AA02 ()
XP-03 ()
Levoprome ()
Neozine ()
NSC-226516 ()
SK&F 5116 ()
Methotrimeprazine hydrochloride ()
Levomepromazine hcl ()
P&D ID
PD009513
CAS
7104-38-3
60-99-1
1236-99-3
Tags
natural product
drug
available
Approved by
FDA
Drug Status
investigational
approved
withdrawn
Drug indication
Analgesic
Psychotic disorder
Bipolar disorder
Max Phase
Phase 4
First approval
1982
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Marketed formulations contain either levomepromazine hydrochloride or levomepromazine maleate. (GtoPdb)
Compound Sets
14
ChEMBL Approved Drugs
CHEMBL1725730
CHEMBL1764
CHEMBL2104973
ChEMBL Drugs
CHEMBL1725730
CHEMBL1764
CHEMBL2104973
Drug Repurposing Hub
DrugBank
DB01403
DrugBank Approved Drugs
DB01403
DrugCentral
1752
DrugCentral Approved Drugs
1752
DrugMAP
DMIKFEL
DrugMAP Approved Drugs
DMIKFEL
Guide to Pharmacology
7603
MedChem Express Bioactive Compound Library
HY-B1693
Prestwick Chemical Library
ReFrame library
Withdrawn 2.0
1360
External IDs
57
Properties
(calculated by RDKit )
Molecular Weight
328.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
4.5
TPSA
15.71
Fraction CSP3
0.37
Chiral centers
1.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
psychosis, schizophrenia, bipolar disorder, nausea, insomnia
Disease Area
neurology/psychiatry, gastroenterology
Target
ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HTR2A, HTR2C
5-HT Receptor
Dopamine Receptor
MOA
Dopamine Receptor antagonist
ATC
N05AA02
Pathway
GPCR/G protein
Neuronal Signaling
Source data