General
Preferred name
CEFEPIME
Synonyms
CEFEPIME HYDROCHLORIDE ()
BMY-28142 ()
Maxipime ()
Renapime ()
VNRX-5022 ()
J01DE01 ()
P&D ID
PD009507
CAS
88040-23-7
Tags
available
drug
Approved by
FDA
First approval
1996
Drug Status
investigational
approved
Drug indication
Bacterial infection
Antibacterial
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
Cefepime is a fourth-generation cephalosporin antibiotic developed in 1994. Cefepime is active against Gram-positive and Gram-negative bacteria, with greater activity against both than third-generation antibiotics. Cefepime has good activity against important pathogens including Pseudomonas aeruginosa, Staphylococcus aureus, Enterobacteriaceae, and multiple drug resistant Streptococcus pneumoniae. Whereas other cephalosporins are degraded by many plasmid- and chromosome-mediated beta-lactamases, cefepime is stable and is a front line agent when infection with Enterobacteriaceae is known or suspected
DESCRIPTION
Cefepime is a semisynthetic, broad-spectrum, fourth-generation cephalosporin antibacterial . It was removed from the World Health Organization's List of Essential Medicines in 2019.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
480.12
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
1
cLogP
-1.28
TPSA
150.04
Fraction CSP3
0.53
Chiral centers
2.0
Largest ring
6.0
QED
0.21
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Antibiotics
Pathway
Anti-infection
Target
antibiotic
Bacterial
Penicillin-binding protein (PBP)
Source data
