General
Preferred name
ACENOCOUMAROL
Synonyms
Mini-sintrom ()
NSC-760052 ()
Sinthrome ()
Acenocumarol ()
Acenocoumarol-d4 ()
P&D ID
PD009504
CAS
152-72-7
2937878-24-3
Tags
drug
available
Drug indication
Recurrent thrombophlebitis
Thrombosis
Drug Status
approved
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION
For the treatment and prevention of thromboembolic diseases. More specifically, it is indicated for the prevention of cerebral embolism, deep vein thrombosis, pulmonary embolism, thromboembolism in infarction and transient ischemic attacks. It is used for the treatment of deep vein thrombosis and myocardial infarction.
DESCRIPTION
Acenocoumarol is a coumarin that is used as an anticoagulant, with actions and uses similar to . The coumarins are vitamin K epoxide reductase antagonists.
(GtoPdb)
DESCRIPTION
Acenocoumarol is an anticoagulant that functions as a Vitamin K antagonist. Acenocoumarol inhibits MAPK/ERK/JNK signaling pathway, reduces the nuclear translocation of NF-¦ÊB p65, activates Akt/GSK3¦Â signaling pathway. Acenocoumarol induces apoptosis in cell A549, arrests cell cycle at S phase[1][2][3][4].
PRICE
33
DESCRIPTION
Acenocoumarol is a Vitamin K antagonist and used as an anticoagulant.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
353.09
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
3.52
TPSA
110.65
Fraction CSP3
0.16
Chiral centers
1.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
vitamin K
Akt
Apoptosis
ERK
GSK-3
JNK
NF-κB
p38 MAPK
PKA
VD/VDR
Therapeutic Class
Anticoagulants
Pathway
Metabolism
MAPK/ERK Pathway
PI3K/Akt/mTOR
Stem Cell/Wnt
TGF-beta/Smad
Vitamin D Related/Nuclear Receptor
NF-¦ÊB
Source data
