General
Preferred name
PAROMOMYCIN
Synonyms
Paromomycin sulfate salt ()
Aminosidine sulfate ()
PAROMOMYCIN SULFATE ()
Paromomycin (sulfate) ()
Aminosidine (sulfate) ()
Aminoxidin ()
Farmiglucin ()
Aminosidine ()
Gabbromycin ()
Pargonyl ()
Sinosid ()
NSC-758421 ()
Gabbromicina ()
Gabbroral ()
Paramicina ()
Paricina ()
Farminosidin ()
Humagel ()
Humatin ()
Paucimycin ()
Gabromycin ()
Paromomycine ()
Aminosidin ()
Monomycin a ()
ANTIBIOTIC SF 767B ()
Quintomycin c ()
R 400 ()
Paromomicina ()
Neomycin e ()
Paromomycin i ()
ANTIBIOTIC 503-3 ()
ANTIBIOTIC SF-767B ()
R-400 ()
Estomycin ()
Hydroxymycin ()
Crestomycin ()
Catenulin ()
P&D ID
PD009501
CAS
1263-89-4
7542-37-2
84420-34-8
Tags
available
drug
natural product
Approved by
FDA
First approval
1969
Drug indication
Intestinal amebiasis
osteomyelitis
Visceral leishmaniasis
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Paromomycin belongs to the aminoglycoside class of antibacterial compounds and was originally isolated from Streptomyces krestomuceticus. It is used as an antiprotozoal drug and is included in the World Health Organization's Model List of Essential Medicines (link provided in the Classification table, under the Summary tab below).
(GtoPdb)
DESCRIPTION
Paromomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA. It is used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma.
(Enamine Bioactive Compounds)
DESCRIPTION
Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. Paromomycin Sulfate (Aminosidine sulfate) is the sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
8
Compound Sets
21
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
68
Molecular Weight
615.3
Hydrogen Bond Acceptors
19
Hydrogen Bond Donors
13
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
0
cLogP
-8.86
TPSA
347.32
Fraction CSP3
1.0
Chiral centers
19.0
Largest ring
6.0
QED
0.11
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
protozoal ribosome inhibitor
Antibacterial inhibitor
bacterial 30S ribosomal subunit inhibitor
Target
Bacterial 70S ribosome
16S rRNA
antibiotic
Bacterial
Parasite
Antibiotics,Antibiotics for Mammalian Cell Culture,Antibiotics for Plant Cell Culture,Selection Antibiotics for Transfected Cell
Indication
amebiasis
Pathway
Microbiology/virology
Anti-infection
Therapeutic Class
Antibiotics
Source data
