General
Preferred name
PAROMOMYCIN
Synonyms
Paromomycin sulfate salt ()
Aminosidine sulfate ()
PAROMOMYCIN SULFATE ()
Paromomycin (sulfate) ()
Aminosidine (sulfate) ()
Gabbroral ()
Humatin ()
NSC-758421 ()
Crestomycin Sulfate ()
Estomycin Sulfate ()
Crestomycin ()
Monomycin a ()
ANTIBIOTIC 503-3 ()
Hydroxymycin ()
R-400 ()
Catenulin ()
ANTIBIOTIC SF 767B ()
Aminosidin ()
Paromomycin i ()
Aminosidine ()
Neomycin e ()
Quintomycin c ()
Monomycin ()
R 400 ()
Gabromycin ()
Paucimycin ()
Estomycin ()
ANTIBIOTIC SF-767B ()
P&D ID
PD009501
CAS
1263-89-4
7542-37-2
84420-34-8
Tags
natural product
drug
available
Approved by
FDA
First approval
1969
Drug Status
investigational
approved
Drug indication
Anti-Amebic
Intestinal amebiasis
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Paromomycin belongs to the aminoglycoside class of antibacterial compounds and was originally isolated from Streptomyces krestomuceticus. It is used as an antiprotozoal drug and is included in the World Health Organization's Model List of Essential Medicines (link provided in the Classification table, under the Summary tab below).
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
7
Compound Sets
19
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
63
Molecular Weight
615.3
Hydrogen Bond Acceptors
19
Hydrogen Bond Donors
13
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
0
cLogP
-8.86
TPSA
347.32
Fraction CSP3
1.0
Chiral centers
19.0
Largest ring
6.0
QED
0.11
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
protozoal ribosome inhibitor
Antibacterial inhibitor
bacterial 30S ribosomal subunit inhibitor
Target
Bacterial 70S ribosome
16S rRNA
antibiotic
Bacterial
Parasite
Antibiotics,Antibiotics for Mammalian Cell Culture,Antibiotics for Plant Cell Culture,Selection Antibiotics for Transfected Cell
Pathway
Microbiology&virology
Anti-infection
Indication
amebiasis
Therapeutic Class
Antibiotics
Source data
