General
Preferred name
ALIZAPRIDE
Synonyms
Alizapride HCl ()
Alizapride hydrochloride ()
Alizapride (hydrochloride) ()
Vergentan ()
Plitican ()
Litican ()
Superan ()
Alizaprida ()
Alizapride-13C-d3 (hydrochloride) ()
P&D ID
PD009499
CAS
59338-87-3
59338-93-1
2928067-18-7
Tags
available
drug
First approval
1981
Drug Status
approved
investigational
Max Phase
3.0
Drug indication
Gastrointestinal disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist. Alizapride also used in human digestive disorders[1][3].
DESCRIPTION Dopamine D2 receptor antagonist with prokinetic and antiemetic effects which can also be used in the treatment of nausea and vomiting, including postoperative nausea and vomiting. The WHO INN record for alizapride provides the CAS registry number 59338-93-1. This CAS number maps to PubChem CID 135413504 (vergentan), which is a tautomer of alizapride. (GtoPdb)
DESCRIPTION Alizapride hydrochloride (Alizapride HCl) is a dopamine receptor antagonist used for the treatment of nausea and vomiting. (TargetMol Bioactive Compound Library)
DESCRIPTION Alizapride is a dopamine antagonist. It has prokinetic and antiemetic effects and is used in the treatment of nausea and vomiting, including postoperative nausea and vomiting. It is structurally related to metoclopramide and other benzamides. It has been listed. (BOC Sciences Bioactive Compounds)
Compound Sets
14
BOC Sciences Bioactive Compounds
alizapride-cas-59338-93-1-item-95176
Cayman Chemical Bioactives
25645
33471
ChEMBL Drugs
CHEMBL290194
DrugBank
DB01425
DrugCentral
120
DrugCentral Approved Drugs
120
DrugMatrix
Guide to Pharmacology
11141
MedChem Express Bioactive Compound Library
HY-A0125A
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
alizapride-hcl
TargetMol Bioactive Compound Library
T2574
External IDs
53
Properties
(calculated by RDKit )
Molecular Weight
315.17
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
1.35
TPSA
83.14
Fraction CSP3
0.44
Chiral centers
1.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
dopamine
Dopamine Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Solubility
Soluble in DMSO, not in water
Source data