General
Preferred name
AJMALINE
Synonyms
Cardiorythmine ()
(+)-Ajmaline ()
P&D ID
PD009498
CAS
4360-12-7
Tags
available
drug
Drug Status
approved
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC50 of 1 ¦ÌM in HEK cells and 42.3 ¦ÌM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia[1][2].
Compound Sets
3
DrugBank
DB01426
DrugBank Approved Drugs
DB01426
MedChem Express Bioactive Compound Library
HY-B1167
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
326.2
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
7
Aromatic Ring Count
1
cLogP
1.55
TPSA
46.94
Fraction CSP3
0.7
Chiral centers
10.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Potassium Channel
Sodium Channel
MOA
Sodium Channel blocker
Pathway
Membrane Transporter/Ion Channel
Source data