General
Preferred name
ALMITRINE
Synonyms
Vectarion ()
S-2620 ()
Almitrine dimesylate ()
ALMITRINE MESYLATE ()
Almitrine bismesylate ()
Almitrine bismethanesulfonate ()
almitrine bismesilate ()
Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate ()
Almitrine dimethanesulfonate ()
Almitrine mesilate ()
Almitrine dimesilate ()
P&D ID
PD009496
CAS
29608-49-9
27469-53-0
Tags
available
drug
Drug Status
approved
withdrawn
Drug indication
Chronic obstructive pulmonary disease
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Almitrine is an agonist at the peripheral chemoreceptors expressed on carotid bodies. It enhances respiration in patients with chronic obstructive pulmonary disease by increasing the arterial oxygen tension while decreasing the arterial carbon dioxide tension.
PHARMACODYNAMICS
Almitrine is a respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
16
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
MedChem Express Bioactive Compound Library
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
46
Molecular Weight
477.25
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
10
Ring Count
4
Aromatic Ring Count
3
cLogP
4.26
TPSA
69.21
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.42
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Target
Potassium Channel
ATP1A1
Indication
chronic obstructive pulmonary disease (COPD)
MOA
neurotransmitter agonist
ATC
R07AB07
Toxicity type
NULL
Therapeutic Class
Antiinflammatory Agents
Source data
