General
Preferred name
phenazopyridine
Synonyms
PHENAZOPYRIDINE HYDROCHLORIDE ()
Urodine ()
Pyridium ()
Phenazopyridine HCl ()
Phenazopyridine (hydrochloride) ()
NC 150 ()
Phenazopyridine hydrochloride component of azo gantrisin ()
W-1655 ()
Uropyrine ()
Phenazopyridine hydrochloride component of azo gantanol ()
W 1655 ()
NSC-1879 ()
NC-150 ()
NSC-145895 ()
Fenazopiridina ()
P&D ID
PD009491
CAS
136-40-3
94-78-0
Tags
available
drug
Approved by
FDA
First approval
1987
2001
Drug Status
approved
withdrawn
Max Phase
4.0
Drug indication
Urinary tract infection
Pain
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Phenazopyridine hydrochlorideis a competitive SARM1 inhibitor, with IC50 145 ¦ÌM. Phenazopyridine hydrochlorideis a TRPM8 antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases[1][2][3][4][5].
PRICE
29
MOA
The full mechanism of action of phenazopyridine is not completely understood; however, it is reported to exert a direct topical analgesic effect on the mucosa lining of the urinary tract.
DESCRIPTION
Phenazopyridine is a competitive SARM1 inhibitor, with IC50 145 ¦ÌM. Phenazopyridine is a TRPM8 antagonist. Phenazopyridine has a local anesthetic/analgesic effect. Phenazopyridine is used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine can promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases[1][2][3][4][5].
DESCRIPTION
Phenazopyridine hydrochloride (Pyridium) is used orally as a urinary tract analgesic. Side effects of phenazopyridine hydrochloride administration can include nausea, interference with the oxygen-carrying capacity of red blood cells (methemoglobinemia), hemolytic anemia as well as renal and hepatic toxicity. It is reasonably anticipated to be a human carcinogen.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
15
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
LSP-MoA library (Laboratory of Systems Pharmacology)
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
213.1
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
2.66
TPSA
89.65
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.75
Structural alerts
3
azo_A(324)
[#7;!R]=[#7]
PAINS Family A
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Target
Sodium Channel
SCN1A
TRP Channel
MOA
Sodium Channel inhibitor
local anesthetic
Indication
urinary tract infections
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data
