General
Preferred name
OXPRENOLOL
Synonyms
OXPRENOLOL HYDROCHLORIDE ()
Oxprenolol ()
Oxprenolol (hydrochloride) ()
oxprenolol, Alza ()
Ba 39089 ()
Oxprenolol HCl ()
Paritane ()
Laracor ()
Slow-Pren ()
Trasicor Ret ()
Apsolox ()
Slow-Trasicor ()
BA-39,089 ()
Trasicor ()
Oxyprenix Excel 160 ()
BA-39089 ()
Oxprenolol-d7 ()
P&D ID
PD009469
CAS
22972-97-0
6452-73-9
22972-96-9
6452-71-7
22972-98-1
1189805-10-4
Tags
natural product
drug
available
Approved by
FDA
Drug Status
approved
withdrawn
Drug indication
Vasodilator (coronary)
Hypertension
Max Phase
Phase 4
First approval
1983
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Oxprenolol is a non-selective beta blocker with some intrinsic sympathomimetic activity. Oxprenolol is a lipophilic molecule and hence, it is able to cross the blood-brain barrier. As such, it is associated with a higher incidence of CNS-related side effects than hydrophilic ligands such as atenolol, sotalol and nadolol. Oxprenolol is an potent beta-blocker and should not be administered to asthmatics because it can cause irreversible airway failure and inflammation.
DESCRIPTION Oxprenolol is a β-adrenoceptor antagonist (β-blocker). (GtoPdb)
DESCRIPTION Oxprenolol is an orally bioavailable and non-selective β-adrenergic receptor (β-AR) inhibitor. It exhibits some intrinsic sympathomimetic activity and is used for the treatment of hypertension, angina pectoris, arrhythmias, and anxiety. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
21
BOC Sciences Bioactive Compounds
oxprenolol-hydrochloride-cas-6452-73-9-item-303284
Cayman Chemical Bioactives
16080
33274
ChEMBL Approved Drugs
CHEMBL1200745
CHEMBL546
ChEMBL Drugs
CHEMBL1200745
CHEMBL546
DrugBank
DB01580
DrugBank Approved Drugs
DB01580
DrugCentral
2027
DrugCentral Approved Drugs
2027
DrugMAP
DM51OQW
DrugMAP Approved Drugs
DM51OQW
DrugMatrix
Guide to Pharmacology
7255
Ki Database
OXPRENOLOL
Mcule NIBR MoA Box Subset
MCULE-3209868387
MedChem Express Bioactive Compound Library
HY-B1486
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
oxprenolol-hcl
Withdrawn 2.0
492
External IDs
49
Properties
(calculated by RDKit )
Molecular Weight
265.17
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
9
Ring Count
1
Aromatic Ring Count
1
cLogP
1.99
TPSA
50.72
Fraction CSP3
0.47
Chiral centers
1.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
beta-Adrenoceptor Antagonists
ATC
C07AA02
Therapeutic Class
Antihypertensive Agents
Pathway
GPCR/G protein
Neuronal Signaling
Target
Adrenergic Receptor
Source data