General
Preferred name
LOPINAVIR
Synonyms
ABT-378 ()
Lopinavir (ABT-378) ()
LOPINAVIR MONOHYDRATE ()
Lopinavir, (s-(2s,4s,5s))- ()
Lopinavir- ()
Kaletra ()
A-157378-0 ()
A-157378.0 ()
Aluviran ()
Koletra ()
Lopinavirum ()
P&D ID
PD009457
CAS
192725-17-0
Tags
natural product
drug
available
Approved by
EMA
FDA
First approval
2000
Drug Status
approved
Drug indication
Human immunodeficiency virus infection
Severe acute respiratory syndrome (SARS)
Middle East Respiratory Syndrome (MERS)
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
This drug is a protease inhibitor. Inhibiting HIV-1 protease (responsible for protein cleavage), results in selectively inhibiting the cleavage of HIV gag and gag-pol polyproteins, thereby preventing viral maturation.
DESCPRITION
An HIV protease inhibitor used in a fixed-dose combination with RITONAVIR. It is also an inhibitor of CYTOCHROME P-450 CYP3A.
DESCRIPTION
Lopinavir is an antiretroviral protease inhibitor. It has subsequently been discovered to exhibit antiviral activity against human papilloma virus (HPV), and to inhibit MERS-CoV replication in vitro . Antiviral activity against SARS-CoV-2 has been explored , however lopinavir/ritonavir therapy provided no benefit in hospitalised COVID-19 patients .
(GtoPdb)
DESCRIPTION
Potent, selective and reversible DCN1-UBC12 interaction inhibitor
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
11
Compound Sets
25
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
46
Molecular Weight
628.36
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
4
Rotatable Bonds
15
Ring Count
4
Aromatic Ring Count
3
cLogP
4.33
TPSA
120.0
Fraction CSP3
0.43
Chiral centers
4.0
Largest ring
6.0
QED
0.2
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Proteases/Proteasome
Anti-infection
Metabolic Enzyme/Protease
Target
HIV Protease
HIV protease inhibitor
HIV
SARS-CoV
COVID-19,HIV Protease
MOA
Inhibitor
HIV Protease inhibitor
Indication
human immunodeficiency virus (HIV-1)
Therapeutic Class
Anti-HIV Agents
Antiviral Agents
Source data
