General
Preferred name
TICARCILLIN
Synonyms
TICARCILLIN DISODIUM ()
Ticarcillin disodium salt ()
Ticarcillin (sodium) ()
TICARCILLIN MONOSODIUM ()
BRL 2288 ()
Ticarcillin disodium component of timentin ()
Monapen ()
Ticarcillin Sodium ()
Ticarpen ()
Ticar ()
Ticillin ()
NSC-759166 ()
Disodium ticarcillin ()
BRL-2288 ()
Ticarcilina ()
Ticarcilline ()
Ticarcillin monosodium monohydrate ()
Ticarcillin dinatrium salt ()
P&D ID
PD009451
CAS
34787-01-4
4697-14-7
29457-07-6
Tags
available
covalent binder
drug
drug candidate
Approved by
FDA
First approval
1976
Drug indication
osteomyelitis
infection
Bacterial infection
Sepsis
Drug Status
vet_approved
approved
investigational
Max Phase
3.0
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ticarcillin sodium is an injectable antibiotic for the treatment of Gram-negative bacteria, particularly Pseudomonas aeruginosa. It is also one of the few antibiotics capable of treating Stenotrophomonas maltophilia infections[1].
MOA
Ticarcillin's principal mechanism of action revolves around its capacity to prevent the cross-linking of peptidoglycan during bacterial cell wall synthesis. Consequently, when the offending bacteria attempt to undergo cell division, cell death occurs.
DESCRIPTION
Ticarcillin is a broad-spectrum, semi-synthetic, parenteral penicillin (β-lactam) antibacterial for the treatment of Gram-negative bacteria. Bacteria that express β-lactamases are resistant to ticarcillin.
(GtoPdb)
DESCRIPTION
Ticarcillin has a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
ChEMBL Approved Drugs
ChEMBL Drugs
CovBinderInPDB
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
ReFrame library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
69
Molecular Weight
384.04
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
1
cLogP
0.55
TPSA
124.01
Fraction CSP3
0.47
Chiral centers
4.0
Largest ring
5.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
gram-negative bacterial infections
MOA
lactamase inhibitor
Therapeutic Class
Antibiotics
Target
antibiotic
Bacterial
Pathway
Anti-infection
Source data
