General
Preferred name
TICARCILLIN
Synonyms
TICARCILLIN DISODIUM ()
Ticarcillin disodium salt ()
BRL-2288 ()
NSC-759166 ()
Ticarpen ()
BRL 2288 ()
Ticar ()
Ticillin ()
Ticarcillin Sodium ()
Monapen ()
Disodium ticarcillin ()
Ticarcilina ()
Ticarcilline ()
Ticarcillin monosodium monohydrate ()
TICARCILLIN MONOSODIUM ()
P&D ID
PD009451
CAS
34787-01-4
4697-14-7
Tags
available
drug
drug candidate
covalent binder
Approved by
FDA
First approval
1976
Drug indication
Antibacterial
Bacterial infection
Drug Status
investigational
vet_approved
approved
Max Phase
4.0
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Ticarcillin's principal mechanism of action revolves around its capacity to prevent the cross-linking of peptidoglycan during bacterial cell wall synthesis. Consequently, when the offending bacteria attempt to undergo cell division, cell death occurs.
DESCRIPTION
Ticarcillin is a broad-spectrum, semi-synthetic, parenteral penicillin (β-lactam) antibacterial for the treatment of Gram-negative bacteria. Bacteria that express β-lactamases are resistant to ticarcillin.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
ChEMBL Approved Drugs
ChEMBL Drugs
CovBinderInPDB
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
ReFrame library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
69
Molecular Weight
384.04
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
1
cLogP
0.55
TPSA
124.01
Fraction CSP3
0.47
Chiral centers
4.0
Largest ring
5.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
gram-negative bacterial infections
MOA
lactamase inhibitor
Therapeutic Class
Antibiotics
Source data
