General
Preferred name
PERICIAZINE
Synonyms
10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile ()
Propericiazine ()
RP 8909 ()
Pericyazine ()
Neulactil ()
Periciazina ()
RP 8909SKF 20716 ()
RP-8909 ()
SKF-20716 ()
NSC-758641 ()
SKF 20716 ()
P&D ID
PD009450
CAS
2622-26-6
Tags
available
drug
Drug indication
Psychiatric disorder
Psychosis
Drug Status
approved
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pericyazine (Propericiazine) is a first-generation antipsychotic agent that is used as an adjunct to the short-term management of severe anxiety states and psychosis[1]. Pericyazine is a selective D2-dopamine receptor antagonist[2][3]. Pericyazine has adrenolytic, anticholinergic, and extrapyramidal effects[4].
PRICE 103
DESCRIPTION Periciazine is a phenothiazine antipsychotic. It has anti-dopaminergic, adrenolytic, anticholinergic, metabolic and endocrine effects. (GtoPdb)
DESCRIPTION Pericyazine (Propericiazine) is a selective D2-dopamine receptor antagonist. Pericyazine is a first-generation antipsychotic drug that is used as an adjunct to the short-term management of severe anxiety states and psychosis. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
15
Cayman Chemical Bioactives
33149
ChEMBL Drugs
CHEMBL251940
DrugBank
DB01608
DrugBank Approved Drugs
DB01608
DrugCentral
2107
DrugCentral Approved Drugs
2107
DrugMAP
DME9JNL
DrugMAP Approved Drugs
DME9JNL
DrugMatrix
Guide to Pharmacology
9216
Ki Database
PROPERICIAZINE
MedChem Express Bioactive Compound Library
HY-14263
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
T16472
External IDs
31
Properties
(calculated by RDKit )
Molecular Weight
365.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
4.01
TPSA
50.5
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.89
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
D2
dopamine
Dopamine Receptor
Therapeutic Class
Antipsychotic Agents
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data