General
Preferred name
MOLINDONE
Synonyms
MOLINDONE HYDROCHLORIDE ()
Minolteparin sodium molindone ()
EN-1733A ()
(±)-Molindone ()
Moban ()
Molindonum ()
SPN-810M ()
Molindone (hydrochloride) ()
Molindone hcl ()
Molindona ()
Spn-810 ()
Molindon ()
P&D ID
PD009446
CAS
15622-65-8
7416-34-4
65973-37-7
Tags
available
drug
Approved by
FDA
First approval
1974
Drug indication
Schizophrenia
Psychosis
Drug Status
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Molindone hydrochloride (EN-1733A) is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses.
PRICE 29
DESCRIPTION Marketed formulations may contain molindone hydrochloride (PubChem CID 9883259). (GtoPdb)
PRICE 516
DESCRIPTION Molindone ((??)-Molindone) is a therapeutic antipsychotic used to treat schizophrenia by blocking the action of dopamine in the brain. molindone is often used in combination with serotonin in a dose-dependent manner to increase errors and decrease response rates.
DESCRIPTION D2 dopamine receptor antagonist; monoamine oxidase inhibitor (LOPAC library)
DESCRIPTION Molindone hydrochloride (EN-1733A) is an indole derivative effective in treating schizophrenia and other psychoses by blocking dopamine's effects in the brain. (TargetMol Bioactive Compound Library)
DESCRIPTION Molindone acts by antagonizing dopamine (D2) receptor sites in the reticular limbic systems in the brain, thus decreasing dopamine activity. Molindone is an indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. (Enamine Bioactive Compounds)
DESCRIPTION Molindone ((±)-Molindone) is a therapeutic antipsychotic used to treat schizophrenia by blocking the action of dopamine in the brain. molindone is often used in combination with serotonin in a dose-dependent manner to increase errors and decrease response rates. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
27
Axon Medchem Screening Library
1101
Cayman Chemical Bioactives
23841
ChEMBL Approved Drugs
CHEMBL1200419
CHEMBL460
ChEMBL Drugs
CHEMBL1200419
CHEMBL460
DrugBank
DB01618
DrugBank Approved Drugs
DB01618
DrugCentral
1830
DrugCentral Approved Drugs
1830
DrugMAP
DMAH70G
DrugMAP Approved Drugs
DMAH70G
DrugMatrix
Enamine Bioactive Compounds
EBC-08260
Enamine BioReference Compounds
Guide to Pharmacology
207
Ki Database
MOLINDONE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL460
MedChem Express Bioactive Compound Library
HY-B1017
NCATS Inxight Approved Drugs
RT3Y3QMF8N
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
molindone-hydrochloride
TargetMol Bioactive Compound Library
T0716
T21432
The Spectrum Collection
Withdrawn 2.0
408
External IDs
57
Properties
(calculated by RDKit )
Molecular Weight
276.18
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
1
cLogP
1.96
TPSA
45.33
Fraction CSP3
0.69
Chiral centers
1.0
Largest ring
6.0
QED
0.92
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D2
Target
5-HT
dopamine
mAChR
Dopamine Receptor
D2 antagonist
ATC
N05AE02
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Therapeutic Class
Antipsychotic Agents
Source data