General
Preferred name
THIOPROPERAZINE
Synonyms
Thioproperazine mesilate ()
Thioproperazine dimesylate ()
RP 7843 ()
SKF 5883 ()
Thioperazine ()
THIOPROPERAZINE MESYLATE ()
Tioproperazina ()
Thioproperazine dimesilate ()
Thioproperazinum ()
Thioperazine mesylate ()
Thioproperazine Methanesulfonate ()
Thioproperazine Dimethanesulfonate ()
NSC-33232 ()
P&D ID
PD009442
CAS
2347-80-0
316-81-4
Tags
drug
drug candidate
available
Drug Status
approved
experimental
investigational
Max Phase
2.0
Drug indication
Psychosis
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Thioproperazine (RP 7843) is an orally active antipsychotic agent with calming, antiemetic activity. Thioproperazine is effective in promoting the release of dopamine in rat striatum. Thioproperazine can be used in studies of schizophrenia and bipolar disorder[1].
PRICE 263
DESCRIPTION Thioproperazine is a drug with the activity of antipsychotic.
Compound Sets
11
ChEMBL Drugs
CHEMBL1481539
CHEMBL609109
Drug Repurposing Hub
DrugBank
DB01622
DrugCentral
2635
DrugCentral Approved Drugs
2635
DrugMatrix
Ki Database
Thioproperazine
MedChem Express Bioactive Compound Library
HY-A0151
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
External IDs
40
Properties
(calculated by RDKit )
Molecular Weight
446.18
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
3.18
TPSA
47.1
Fraction CSP3
0.45
Chiral centers
0.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ADRA1A, ADRA1B, DRD1, DRD2, HTR1A, HTR2A
Dopamine Receptor
Indication
schizophrenia
MOA
Dopamine Receptor antagonist
Pathway
GPCR/G protein
Neuronal Signaling
Source data