General
Preferred name
FLOCTAFENINE
Synonyms
RU 15750 ()
R-4318 ()
R 4318 ()
RU-15750 ()
R4318 ()
Floctafenin ()
Idarac ()
Diralgan ()
Floctafenina ()
R-4138 ()
Novodolan ()
Idalon ()
P&D ID
PD009426
CAS
23779-99-9
Tags
available
drug
Drug Status
approved
withdrawn
investigational
Max Phase
2.0
Drug indication
Pain
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 887
DESCRIPTION Floctafenine (R-4318) is an orally available nonsteroidal anti-inflammatory compound that is a COX-I and COX-2 inhibitor and interferes with the antiplatelet effects of aspirin.Floctafenine has analgesic activity and is used in the study of pain. (TargetMol Bioactive Compound Library)
Compound Sets
9
ChEMBL Drugs
CHEMBL2105075
DrugBank
DB08976
DrugBank Approved Drugs
DB08976
DrugCentral
1178
DrugCentral Approved Drugs
1178
DrugMatrix
ReFrame library
TargetMol Bioactive Compound Library
T27335
Withdrawn 2.0
w278
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
406.11
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
3.51
TPSA
91.68
Fraction CSP3
0.2
Chiral centers
1.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
COX-1
COX-2
ATC
N02BG04
Toxicity type
dermatological
Pathway
Immunology/Inflammation
Neuroscience
Source data